DegronMD

Uniprot ID: Q9BRJ6

Source protein: Uncharacterized protein C7orf50

Source gene: C7orf50

Class: DEG_APCC_DBOX_1

Location: 186:194

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9482

ASA_SCORE: 78.2667

COIL: 0.2416

CONS_SCORE: 0.4848

DSS_SCORE: 0.6821

HELIX: 0.7569

FCONS_SCORE: 1.1982

RIG_SCORE: 0.8087

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P178S	TCGA-FS-A1ZK	SKCM	TCGA	IRQVLQLLS	DEG_APCC_DBOX_1	0.1111
p.P178S	DO37474	SKCM	ICGC	IRQVLQLLS	DEG_APCC_DBOX_1	0.1111
p.R187Q	TCGA-ZX-AA5X	CESC	TCGA	IRQVLQLLS	DEG_APCC_DBOX_1	0.7329
p.R187Q	DO219762	CESC	ICGC	IRQVLQLLS	DEG_APCC_DBOX_1	0.7329
p.P180T	DO229035	LICA	ICGC	IRQVLQLLS	DEG_APCC_DBOX_1	0.1667
p.P177A	DO220912	MELA	ICGC	IRQVLQLLS	DEG_APCC_DBOX_1	0.0833
p.R185C	DO43763	UCEC	ICGC	IRQVLQLLS	DEG_APCC_DBOX_1	0.3056
p.D176N	SIDM01127	Non-Small Cell Lung Carcinoma	GDSC	IRQVLQLLS	DEG_APCC_DBOX_1	0.0556
p.D176N	ACH-000628	Lung Cancer	CCLE	IRQVLQLLS	DEG_APCC_DBOX_1	0.0556
p.P178R	SIDM00205	Ewing's Sarcoma	GDSC	IRQVLQLLS	DEG_APCC_DBOX_1	0.1111
p.P178R	ACH-002110	Bone Cancer	CCLE	IRQVLQLLS	DEG_APCC_DBOX_1	0.1111
p.P180L	SIDM00359	Colorectal Carcinoma	GDSC	IRQVLQLLS	DEG_APCC_DBOX_1	0.1667
p.P178L	ACH-000945	Lung Cancer	CCLE	IRQVLQLLS	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BRJ6	Uncharacterized protein C7orf50	DEG_APCC_DBOX_1	186:194	IRQVLQLLS	APC,CDC20,FZR1	0.9482	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons