DegronMD - Q9BRK3(MXRA8)

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GO - Molecular function (MF): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A427V	TCGA-AP-A1DV	UCEC	TCGA	RKENC	DEG_APCC_KENBOX_2	437:441	Mutation rewiring degron network	0.0556
p.K438T	TCGA-AX-A2HC	UCEC	TCGA	RKENC	DEG_APCC_KENBOX_2	437:441	Mutation altering degron motif	0.7306
p.I430M	TCGA-C5-A7CL	CESC	TCGA	RKENC	DEG_APCC_KENBOX_2	437:441	Mutation rewiring degron network	0.1389
p.D431N	TCGA-EO-A22U	UCEC	TCGA	RKENC	DEG_APCC_KENBOX_2	437:441	Mutation rewiring degron network	0.1667
p.G444E	DO219892	DLBC	ICGC	RKENC	DEG_APCC_KENBOX_2	437:441	Mutation rewiring degron network	0.25
p.K429T	DO41572	UCEC	ICGC	RKENC	DEG_APCC_KENBOX_2	437:441	Mutation blocking phosphorylation signal	0.5556
p.S429N	SIDM00946	T-Lymphoblastic Leukemia	GDSC	RKENC	DEG_APCC_KENBOX_2	437:441	Mutation blocking phosphorylation signal	0.5556
p.S429N	SIDM00145	T-Lymphoblastic Leukemia	GDSC	RKENC	DEG_APCC_KENBOX_2	437:441	Mutation blocking phosphorylation signal	0.5556
p.S429N	DND-41	haematopoietic and lymphoid tissue	COSMIC	RKENC	DEG_APCC_KENBOX_2	437:441	Mutation blocking phosphorylation signal	0.5556
p.S429N	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	RKENC	DEG_APCC_KENBOX_2	437:441	Mutation blocking phosphorylation signal	0.5556

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons