DegronMD

Uniprot ID: Q9BRK3

Source protein: Matrix remodeling-associated protein 8

Source gene: MXRA8

Class: DEG_APCC_KENBOX_2

Location: 437:441

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6581

ASA_SCORE: 111.58

COIL: 0.7178

CONS_SCORE: 0.6374

DSS_SCORE: 0.6754

HELIX: 0.2174

FCONS_SCORE: 0.8798

RIG_SCORE: 0.7663

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A427V	TCGA-AP-A1DV	UCEC	TCGA	RKENC	DEG_APCC_KENBOX_2	0.0556
p.K438T	TCGA-AX-A2HC	UCEC	TCGA	RKENC	DEG_APCC_KENBOX_2	0.7306
p.I430M	TCGA-C5-A7CL	CESC	TCGA	RKENC	DEG_APCC_KENBOX_2	0.1389
p.D431N	TCGA-EO-A22U	UCEC	TCGA	RKENC	DEG_APCC_KENBOX_2	0.1667
p.G444E	DO219892	DLBC	ICGC	RKENC	DEG_APCC_KENBOX_2	0.25
p.K429T	DO41572	UCEC	ICGC	RKENC	DEG_APCC_KENBOX_2	0.5556
p.S429N	SIDM00946	T-Lymphoblastic Leukemia	GDSC	RKENC	DEG_APCC_KENBOX_2	0.5556
p.S429N	SIDM00145	T-Lymphoblastic Leukemia	GDSC	RKENC	DEG_APCC_KENBOX_2	0.5556
p.S429N	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	RKENC	DEG_APCC_KENBOX_2	0.5556
p.S429N	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	RKENC	DEG_APCC_KENBOX_2	0.5556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BRK3	Matrix remodeling-associated protein 8	DEG_APCC_KENBOX_2	437:441	RKENC	APC,CDC20,FZR1	0.6581	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons