DegronMD - Q9BRR0(ZKSCAN3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G235E	TCGA-AP-A0LM	UCEC	TCGA	LTLTPEWT	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.1389
p.G235E	DO43306	UCEC	ICGC	LTLTPEWT	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.1389
p.G212W	TCGA-DA-A1I1	SKCM	TCGA	LTLTPEWT	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.0833
p.G212W	DO37966	SKCM	ICGC	LTLTPEWT	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.0833
p.W227L	TCGA-FS-A1ZM	SKCM	TCGA	LTLTPEWT	DEG_SCF_FBW7_1	221:228	Mutation altering degron motif	0.5904
p.W227L	DO37731	SKCM	ICGC	LTLTPEWT	DEG_SCF_FBW7_1	221:228	Mutation altering degron motif	0.5904
p.S232L	TCGA-OR-A5JB	ACC	TCGA	LTLTPEWT	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.2222
p.Q229H	DO8858	COAD	ICGC	LTLTPEWT	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.3056
p.T228A	DO234219	ESAD	ICGC	LTLTPEWT	DEG_SCF_FBW7_1	221:228	Mutation altering degron motif	0.825
p.G235V	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	LTLTPEWT	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.1389
p.G235V	ACH-000924	Lung Cancer	CCLE	LTLTPEWT	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.1389
p.G235V	NCI-H2172	lung	COSMIC	LTLTPEWT	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.1389
p.D218A	SIDM01007	T-Lymphoblastic Leukemia	GDSC	LTLTPEWT	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.25
p.D218A	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	LTLTPEWT	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.25
p.T222I	SIDM01055	Glioblastoma	GDSC	LTLTPEWT	DEG_SCF_FBW7_1	221:228	Mutation altering degron motif	0.7078
p.T222I	GAMG	central nervous system	COSMIC	LTLTPEWT	DEG_SCF_FBW7_1	221:228	Mutation altering degron motif	0.7078
p.V216M	SIDM00032	Bladder Carcinoma	GDSC	LTLTPEWT	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.1944
p.V216M	ACH-000839	Bladder Cancer	CCLE	LTLTPEWT	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.1944
p.V216M	SCaBER	urinary tract	COSMIC	LTLTPEWT	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.1944

Kaplan plot for ZKSCAN3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZKSCAN3

UniProt ID: Q9BRR0

Entrez ID: 80317

Protein name: Zinc finger protein with KRAB and SCAN domains 3 (Zinc finger and SCAN domain-containing protein 13) (Zinc finger protein 306) (Zinc finger protein 309) (Zinc finger protein 47 homolog) (Zf47) (Zfp-47)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZKSCAN3 in