DegronMD

Uniprot ID: Q9BRR0

Source protein: Zinc finger protein with KRAB and SCAN domains 3

Source gene: ZKSCAN3

Class: DEG_SCF_FBW7_1

Location: 221:228

E3 ligase: FBXW7

DEGRON score: 0.694

ASA_SCORE: 69.475

COIL: 0.5103

CONS_SCORE: 0.7395

DSS_SCORE: 0.4514

HELIX: 0.256

FCONS_SCORE: 0.8939

RIG_SCORE: 0.7941

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G235E	TCGA-AP-A0LM	UCEC	TCGA	LTLTPEWT	DEG_SCF_FBW7_1	0.1389
p.G235E	DO43306	UCEC	ICGC	LTLTPEWT	DEG_SCF_FBW7_1	0.1389
p.G212W	TCGA-DA-A1I1	SKCM	TCGA	LTLTPEWT	DEG_SCF_FBW7_1	0.0833
p.G212W	DO37966	SKCM	ICGC	LTLTPEWT	DEG_SCF_FBW7_1	0.0833
p.W227L	TCGA-FS-A1ZM	SKCM	TCGA	LTLTPEWT	DEG_SCF_FBW7_1	0.5904
p.W227L	DO37731	SKCM	ICGC	LTLTPEWT	DEG_SCF_FBW7_1	0.5904
p.S232L	TCGA-OR-A5JB	ACC	TCGA	LTLTPEWT	DEG_SCF_FBW7_1	0.2222
p.Q229H	DO8858	COAD	ICGC	LTLTPEWT	DEG_SCF_FBW7_1	0.3056
p.T228A	DO234219	ESAD	ICGC	LTLTPEWT	DEG_SCF_FBW7_1	0.825
p.G235V	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	LTLTPEWT	DEG_SCF_FBW7_1	0.1389
p.G235V	ACH-000924	Lung Cancer	CCLE	LTLTPEWT	DEG_SCF_FBW7_1	0.1389
p.G235V	NCI-H2172	lung	COSMIC	LTLTPEWT	DEG_SCF_FBW7_1	0.1389
p.D218A	SIDM01007	T-Lymphoblastic Leukemia	GDSC	LTLTPEWT	DEG_SCF_FBW7_1	0.25
p.D218A	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	LTLTPEWT	DEG_SCF_FBW7_1	0.25
p.T222I	SIDM01055	Glioblastoma	GDSC	LTLTPEWT	DEG_SCF_FBW7_1	0.7078
p.T222I	GAMG	central_nervous_system	COSMIC	LTLTPEWT	DEG_SCF_FBW7_1	0.7078
p.V216M	SIDM00032	Bladder Carcinoma	GDSC	LTLTPEWT	DEG_SCF_FBW7_1	0.1944
p.V216M	ACH-000839	Bladder Cancer	CCLE	LTLTPEWT	DEG_SCF_FBW7_1	0.1944
p.V216M	SCaBER	urinary_tract	COSMIC	LTLTPEWT	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BRR0	Zinc finger protein with KRAB and SCAN domains 3	DEG_SCF_FBW7_1	221:228	LTLTPEWT	FBXW7	0.694	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons