DegronMD - Q9BS31(ZNF649)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V306A	TCGA-95-7567	LUAD	TCGA	SRKSLLVVH	DEG_APCC_DBOX_1	300:308	Mutation altering degron motif	0.5825
p.V306A	DO25564	LUAD	ICGC	SRKSLLVVH	DEG_APCC_DBOX_1	300:308	Mutation altering degron motif	0.5825
p.C295Y	TCGA-A5-A0G2	UCEC	TCGA	SRKSLLVVH	DEG_APCC_DBOX_1	300:308	Mutation rewiring degron network	0.1944
p.C295Y	TCGA-B5-A0K2	UCEC	TCGA	SRKSLLVVH	DEG_APCC_DBOX_1	300:308	Mutation rewiring degron network	0.1944
p.C295Y	DO41235	UCEC	ICGC	SRKSLLVVH	DEG_APCC_DBOX_1	300:308	Mutation rewiring degron network	0.1944
p.C295Y	DO43835	UCEC	ICGC	SRKSLLVVH	DEG_APCC_DBOX_1	300:308	Mutation rewiring degron network	0.1944
p.R297I	TCGA-AP-A059	UCEC	TCGA	SRKSLLVVH	DEG_APCC_DBOX_1	300:308	Mutation rewiring degron network	0.25
p.R297I	DO41361	UCEC	ICGC	SRKSLLVVH	DEG_APCC_DBOX_1	300:308	Mutation rewiring degron network	0.25
p.R310Q	TCGA-CA-6717	COAD	TCGA	SRKSLLVVH	DEG_APCC_DBOX_1	300:308	Mutation rewiring degron network	0.2778
p.R310Q	TCGA-D1-A16Y	UCEC	TCGA	SRKSLLVVH	DEG_APCC_DBOX_1	300:308	Mutation rewiring degron network	0.2778
p.R310Q	TCGA-EI-6917	READ	TCGA	SRKSLLVVH	DEG_APCC_DBOX_1	300:308	Mutation rewiring degron network	0.2778
p.R310Q	DO8264	COAD	ICGC	SRKSLLVVH	DEG_APCC_DBOX_1	300:308	Mutation rewiring degron network	0.2778
p.R310Q	DO36881	READ	ICGC	SRKSLLVVH	DEG_APCC_DBOX_1	300:308	Mutation rewiring degron network	0.2778
p.R310Q	DO41524	UCEC	ICGC	SRKSLLVVH	DEG_APCC_DBOX_1	300:308	Mutation rewiring degron network	0.2778
p.V306I	TCGA-CK-6746	COAD	TCGA	SRKSLLVVH	DEG_APCC_DBOX_1	300:308	Mutation altering degron motif	0.5965
p.V306I	DO7938	COAD	ICGC	SRKSLLVVH	DEG_APCC_DBOX_1	300:308	Mutation altering degron motif	0.5965
p.V306I	SIDM00327	Hodgkin's Lymphoma	GDSC	SRKSLLVVH	DEG_APCC_DBOX_1	300:308	Mutation altering degron motif	0.5965
p.V306I	ACH-000754	Lymphoma	CCLE	SRKSLLVVH	DEG_APCC_DBOX_1	300:308	Mutation altering degron motif	0.5965
p.V306I	L-428	haematopoietic and lymphoid tissue	COSMIC	SRKSLLVVH	DEG_APCC_DBOX_1	300:308	Mutation altering degron motif	0.5965
p.H290N	TCGA-D3-A1Q3	SKCM	TCGA	SRKSLLVVH	DEG_APCC_DBOX_1	300:308	Mutation rewiring degron network	0.0556
p.H290N	DO47509	SKCM	ICGC	SRKSLLVVH	DEG_APCC_DBOX_1	300:308	Mutation rewiring degron network	0.0556
p.R301T	TCGA-E9-A1N8	BRCA	TCGA	SRKSLLVVH	DEG_APCC_DBOX_1	300:308	Mutation altering degron motif	0.7876
p.R301T	DO3019	BRCA	ICGC	SRKSLLVVH	DEG_APCC_DBOX_1	300:308	Mutation altering degron motif	0.7876
p.H318D	TCGA-GC-A3BM	BLCA	TCGA	SRKSLLVVH	DEG_APCC_DBOX_1	300:308	Mutation rewiring degron network	0.0556
p.H318D	DO446	BLCA	ICGC	SRKSLLVVH	DEG_APCC_DBOX_1	300:308	Mutation rewiring degron network	0.0556
p.P317H	TCGA-VQ-A8P2	STAD	TCGA	SRKSLLVVH	DEG_APCC_DBOX_1	300:308	Mutation rewiring degron network	0.0833
p.P317H	DO51761	STAD	ICGC	SRKSLLVVH	DEG_APCC_DBOX_1	300:308	Mutation rewiring degron network	0.0833
p.S300Y	TCGA-WE-A8K4	SKCM	TCGA	SRKSLLVVH	DEG_APCC_DBOX_1	300:308	Mutation altering degron motif	0.6009
p.S300Y	DO51281	SKCM	ICGC	SRKSLLVVH	DEG_APCC_DBOX_1	300:308	Mutation altering degron motif	0.6009
p.Q309K	DO229038	LICA	ICGC	SRKSLLVVH	DEG_APCC_DBOX_1	300:308	Mutation rewiring degron network	0.3056

Kaplan plot for ZNF649 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF649

UniProt ID: Q9BS31

Entrez ID: 65251

Protein name: Zinc finger protein 649

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ZNF649 in