DegronMD

Uniprot ID: Q9BS31

Source protein: Zinc finger protein 649

Source gene: ZNF649

Class: DEG_APCC_DBOX_1

Location: 300:308

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9411

ASA_SCORE: 71.5556

COIL: 0.6527

CONS_SCORE: 0.6078

DSS_SCORE: 0.3595

HELIX: 0.0417

FCONS_SCORE: 0.7696

RIG_SCORE: 0.7693

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V306A	TCGA-95-7567	LUAD	TCGA	SRKSLLVVH	DEG_APCC_DBOX_1	0.5825
p.V306A	DO25564	LUAD	ICGC	SRKSLLVVH	DEG_APCC_DBOX_1	0.5825
p.C295Y	TCGA-A5-A0G2	UCEC	TCGA	SRKSLLVVH	DEG_APCC_DBOX_1	0.1944
p.C295Y	TCGA-B5-A0K2	UCEC	TCGA	SRKSLLVVH	DEG_APCC_DBOX_1	0.1944
p.C295Y	DO41235	UCEC	ICGC	SRKSLLVVH	DEG_APCC_DBOX_1	0.1944
p.C295Y	DO43835	UCEC	ICGC	SRKSLLVVH	DEG_APCC_DBOX_1	0.1944
p.R297I	TCGA-AP-A059	UCEC	TCGA	SRKSLLVVH	DEG_APCC_DBOX_1	0.25
p.R297I	DO41361	UCEC	ICGC	SRKSLLVVH	DEG_APCC_DBOX_1	0.25
p.R310Q	TCGA-CA-6717	COAD	TCGA	SRKSLLVVH	DEG_APCC_DBOX_1	0.2778
p.R310Q	TCGA-D1-A16Y	UCEC	TCGA	SRKSLLVVH	DEG_APCC_DBOX_1	0.2778
p.R310Q	TCGA-EI-6917	READ	TCGA	SRKSLLVVH	DEG_APCC_DBOX_1	0.2778
p.R310Q	DO8264	COAD	ICGC	SRKSLLVVH	DEG_APCC_DBOX_1	0.2778
p.R310Q	DO36881	READ	ICGC	SRKSLLVVH	DEG_APCC_DBOX_1	0.2778
p.R310Q	DO41524	UCEC	ICGC	SRKSLLVVH	DEG_APCC_DBOX_1	0.2778
p.V306I	TCGA-CK-6746	COAD	TCGA	SRKSLLVVH	DEG_APCC_DBOX_1	0.5965
p.V306I	DO7938	COAD	ICGC	SRKSLLVVH	DEG_APCC_DBOX_1	0.5965
p.V306I	SIDM00327	Hodgkin's Lymphoma	GDSC	SRKSLLVVH	DEG_APCC_DBOX_1	0.5965
p.V306I	ACH-000754	Lymphoma	CCLE	SRKSLLVVH	DEG_APCC_DBOX_1	0.5965
p.V306I	L-428	haematopoietic_and_lymphoid_tissue	COSMIC	SRKSLLVVH	DEG_APCC_DBOX_1	0.5965
p.H290N	TCGA-D3-A1Q3	SKCM	TCGA	SRKSLLVVH	DEG_APCC_DBOX_1	0.0556
p.H290N	DO47509	SKCM	ICGC	SRKSLLVVH	DEG_APCC_DBOX_1	0.0556
p.R301T	TCGA-E9-A1N8	BRCA	TCGA	SRKSLLVVH	DEG_APCC_DBOX_1	0.7876
p.R301T	DO3019	BRCA	ICGC	SRKSLLVVH	DEG_APCC_DBOX_1	0.7876
p.H318D	TCGA-GC-A3BM	BLCA	TCGA	SRKSLLVVH	DEG_APCC_DBOX_1	0.0556
p.H318D	DO446	BLCA	ICGC	SRKSLLVVH	DEG_APCC_DBOX_1	0.0556
p.P317H	TCGA-VQ-A8P2	STAD	TCGA	SRKSLLVVH	DEG_APCC_DBOX_1	0.0833
p.P317H	DO51761	STAD	ICGC	SRKSLLVVH	DEG_APCC_DBOX_1	0.0833
p.S300Y	TCGA-WE-A8K4	SKCM	TCGA	SRKSLLVVH	DEG_APCC_DBOX_1	0.6009
p.S300Y	DO51281	SKCM	ICGC	SRKSLLVVH	DEG_APCC_DBOX_1	0.6009
p.Q309K	DO229038	LICA	ICGC	SRKSLLVVH	DEG_APCC_DBOX_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRKSLLVVH

Degron related mutations and impact score

Drug responses associated with ZNF649 mutations

All proteins holding degron of SRKSLLVVH

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BS31	Zinc finger protein 649	DEG_APCC_DBOX_1	300:308	SRKSLLVVH	APC,CDC20,FZR1	0.9411	More...