DegronMD - Q9BSJ1(TRIM51)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N213D	TCGA-22-1016	LUSC	TCGA	SRELLRGMY	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.0833
p.Q235K	TCGA-69-7973	LUAD	TCGA	SRELLRGMY	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.1944
p.R223M	TCGA-78-7146	LUAD	TCGA	SRELLRGMY	DEG_APCC_DBOX_1	222:230	Mutation altering degron motif	0.8632
p.K239E	TCGA-78-7161	LUAD	TCGA	SRELLRGMY	DEG_APCC_DBOX_1	222:230	Mutation substituting flanking lysine	0.1944
p.A240S	TCGA-AA-3984	COAD	TCGA	SRELLRGMY	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.0556
p.M219T	TCGA-BS-A0UV	UCEC	TCGA	SRELLRGMY	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.25
p.S222F	TCGA-D3-A8GB	SKCM	TCGA	SRELLRGMY	DEG_APCC_DBOX_1	222:230	Mutation altering degron motif	0.6871
p.S215N	TCGA-EE-A20F	SKCM	TCGA	SRELLRGMY	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.1389
p.R227I	TCGA-EY-A1GI	UCEC	TCGA	SRELLRGMY	DEG_APCC_DBOX_1	222:230	Mutation altering degron motif	0.6991
p.R218T	TCGA-GU-A764	BLCA	TCGA	SRELLRGMY	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.2222
p.M229T	TCGA-GV-A3JX	BLCA	TCGA	SRELLRGMY	DEG_APCC_DBOX_1	222:230	Mutation altering degron motif	0.7423
p.E231K	DO1579	BRCA	ICGC	SRELLRGMY	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.3056
p.E231K	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	SRELLRGMY	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.3056
p.E231K	ACH-002215	Lymphoma	CCLE	SRELLRGMY	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.3056
p.E231K	BC-3	haematopoietic and lymphoid tissue	COSMIC	SRELLRGMY	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.3056
p.W219R	DO10590	COAD	ICGC	SRELLRGMY	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.25
p.E221G	DO50342	ESAD	ICGC	SRELLRGMY	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.3056
p.D226G	DO13863	GBM	ICGC	SRELLRGMY	DEG_APCC_DBOX_1	222:230	Mutation altering degron motif	0.7198
p.D229H	DO15791	HNSC	ICGC	SRELLRGMY	DEG_APCC_DBOX_1	222:230	Mutation altering degron motif	0.7688
p.L234I	DO14216	HNSC	ICGC	SRELLRGMY	DEG_APCC_DBOX_1	222:230	Mutation substituting flanking lysine	0.3333
p.G238R	DO23566	LUAD	ICGC	SRELLRGMY	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.1111
p.C239Y	DO26617	LUSC	ICGC	SRELLRGMY	DEG_APCC_DBOX_1	222:230	Mutation substituting flanking lysine	0.1944
p.R223K	DO222632	MELA	ICGC	SRELLRGMY	DEG_APCC_DBOX_1	222:230	Mutation altering degron motif	0.7237
p.L236F	DO219501	SKCM	ICGC	SRELLRGMY	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.1667
p.L236R	DO38695	STAD	ICGC	SRELLRGMY	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.1667
p.V214A	DO41752	UCEC	ICGC	SRELLRGMY	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.1111
p.L236V	DO52421	UCEC	ICGC	SRELLRGMY	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.1667
p.L237I	DO42793	UCEC	ICGC	SRELLRGMY	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.1389
p.K234N	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	SRELLRGMY	DEG_APCC_DBOX_1	222:230	Mutation substituting flanking lysine	0.3333
p.K234N	ACH-000852	Lung Cancer	CCLE	SRELLRGMY	DEG_APCC_DBOX_1	222:230	Mutation substituting flanking lysine	0.3333
p.K234N	NCI-H1435	lung	COSMIC	SRELLRGMY	DEG_APCC_DBOX_1	222:230	Mutation substituting flanking lysine	0.3333
p.E220K	ACH-000055	Brain Cancer	CCLE	SRELLRGMY	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.2778
p.E232K	HCC-15	lung	COSMIC	SRELLRGMY	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.2778
p.E221D	GB-1	central nervous system	COSMIC	SRELLRGMY	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.3056
p.G230R	SF295	central nervous system	COSMIC	SRELLRGMY	DEG_APCC_DBOX_1	222:230	Mutation altering degron motif	0.7568
p.D229A	BB65-RCC	kidney	COSMIC	SRELLRGMY	DEG_APCC_DBOX_1	222:230	Mutation altering degron motif	0.7793
p.E231Q	HCC38	breast	COSMIC	SRELLRGMY	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TRIM51

UniProt ID: Q9BSJ1

Entrez ID: 84767

Protein name: Tripartite motif-containing protein 51 (SPRY domain-containing protein 5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TRIM51 in