DegronMD

Uniprot ID: Q9BSJ1

Source protein: Tripartite motif-containing protein 51

Source gene: TRIM51

Class: DEG_APCC_DBOX_1

Location: 222:230

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5443

ASA_SCORE: 75.0778

COIL: 0.008

CONS_SCORE: 0.5337

DSS_SCORE: 0.3247

HELIX: 0.9918

FCONS_SCORE: 1.2148

RIG_SCORE: 0.7679

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N213D	TCGA-22-1016	LUSC	TCGA	SRELLRGMY	DEG_APCC_DBOX_1	0.0833
p.Q235K	TCGA-69-7973	LUAD	TCGA	SRELLRGMY	DEG_APCC_DBOX_1	0.1944
p.R223M	TCGA-78-7146	LUAD	TCGA	SRELLRGMY	DEG_APCC_DBOX_1	0.8632
p.K239E	TCGA-78-7161	LUAD	TCGA	SRELLRGMY	DEG_APCC_DBOX_1	0.1944
p.A240S	TCGA-AA-3984	COAD	TCGA	SRELLRGMY	DEG_APCC_DBOX_1	0.0556
p.M219T	TCGA-BS-A0UV	UCEC	TCGA	SRELLRGMY	DEG_APCC_DBOX_1	0.25
p.S222F	TCGA-D3-A8GB	SKCM	TCGA	SRELLRGMY	DEG_APCC_DBOX_1	0.6871
p.S215N	TCGA-EE-A20F	SKCM	TCGA	SRELLRGMY	DEG_APCC_DBOX_1	0.1389
p.R227I	TCGA-EY-A1GI	UCEC	TCGA	SRELLRGMY	DEG_APCC_DBOX_1	0.6991
p.R218T	TCGA-GU-A764	BLCA	TCGA	SRELLRGMY	DEG_APCC_DBOX_1	0.2222
p.M229T	TCGA-GV-A3JX	BLCA	TCGA	SRELLRGMY	DEG_APCC_DBOX_1	0.7423
p.E231K	DO1579	BRCA	ICGC	SRELLRGMY	DEG_APCC_DBOX_1	0.3056
p.E231K	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	SRELLRGMY	DEG_APCC_DBOX_1	0.3056
p.E231K	ACH-002215	Lymphoma	CCLE	SRELLRGMY	DEG_APCC_DBOX_1	0.3056
p.E231K	BC-3	haematopoietic_and_lymphoid_tissue	COSMIC	SRELLRGMY	DEG_APCC_DBOX_1	0.3056
p.W219R	DO10590	COAD	ICGC	SRELLRGMY	DEG_APCC_DBOX_1	0.25
p.E221G	DO50342	ESAD	ICGC	SRELLRGMY	DEG_APCC_DBOX_1	0.3056
p.D226G	DO13863	GBM	ICGC	SRELLRGMY	DEG_APCC_DBOX_1	0.7198
p.D229H	DO15791	HNSC	ICGC	SRELLRGMY	DEG_APCC_DBOX_1	0.7688
p.L234I	DO14216	HNSC	ICGC	SRELLRGMY	DEG_APCC_DBOX_1	0.3333
p.G238R	DO23566	LUAD	ICGC	SRELLRGMY	DEG_APCC_DBOX_1	0.1111
p.C239Y	DO26617	LUSC	ICGC	SRELLRGMY	DEG_APCC_DBOX_1	0.1944
p.R223K	DO222632	MELA	ICGC	SRELLRGMY	DEG_APCC_DBOX_1	0.7237
p.L236F	DO219501	SKCM	ICGC	SRELLRGMY	DEG_APCC_DBOX_1	0.1667
p.L236R	DO38695	STAD	ICGC	SRELLRGMY	DEG_APCC_DBOX_1	0.1667
p.V214A	DO41752	UCEC	ICGC	SRELLRGMY	DEG_APCC_DBOX_1	0.1111
p.L236V	DO52421	UCEC	ICGC	SRELLRGMY	DEG_APCC_DBOX_1	0.1667
p.L237I	DO42793	UCEC	ICGC	SRELLRGMY	DEG_APCC_DBOX_1	0.1389
p.K234N	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	SRELLRGMY	DEG_APCC_DBOX_1	0.3333
p.K234N	ACH-000852	Lung Cancer	CCLE	SRELLRGMY	DEG_APCC_DBOX_1	0.3333
p.K234N	NCI-H1435	lung	COSMIC	SRELLRGMY	DEG_APCC_DBOX_1	0.3333
p.E220K	ACH-000055	Brain Cancer	CCLE	SRELLRGMY	DEG_APCC_DBOX_1	0.2778
p.E232K	HCC-15	lung	COSMIC	SRELLRGMY	DEG_APCC_DBOX_1	0.2778
p.E221D	GB-1	central_nervous_system	COSMIC	SRELLRGMY	DEG_APCC_DBOX_1	0.3056
p.G230R	SF295	central_nervous_system	COSMIC	SRELLRGMY	DEG_APCC_DBOX_1	0.7568
p.D229A	BB65-RCC	kidney	COSMIC	SRELLRGMY	DEG_APCC_DBOX_1	0.7793
p.E231Q	HCC38	breast	COSMIC	SRELLRGMY	DEG_APCC_DBOX_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRELLRGMY

Degron related mutations and impact score

Drug responses associated with TRIM51 mutations

All proteins holding degron of SRELLRGMY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BSJ1	Tripartite motif-containing protein 51	DEG_APCC_DBOX_1	222:230	SRELLRGMY	APC,CDC20,FZR1	0.5443	More...