DegronMD - Q9BST9(RTKN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E346K	TCGA-AC-A23H	BRCA	TCGA	DADTGE	DEG_Kelch_Keap1_1	347:352	Mutation rewiring degron network	0.3056
p.E346K	DO2401	BRCA	ICGC	DADTGE	DEG_Kelch_Keap1_1	347:352	Mutation rewiring degron network	0.3056
p.P345H	TCGA-AX-A1C4	UCEC	TCGA	DADTGE	DEG_Kelch_Keap1_1	347:352	Mutation rewiring degron network	0.2778
p.P345H	TCGA-D3-A2JP	SKCM	TCGA	DADTGE	DEG_Kelch_Keap1_1	347:352	Mutation rewiring degron network	0.2778
p.P345H	DO47407	SKCM	ICGC	DADTGE	DEG_Kelch_Keap1_1	347:352	Mutation rewiring degron network	0.2778
p.P345H	DO42480	UCEC	ICGC	DADTGE	DEG_Kelch_Keap1_1	347:352	Mutation rewiring degron network	0.2778
p.P354Q	TCGA-D3-A2JC	SKCM	TCGA	DADTGE	DEG_Kelch_Keap1_1	347:352	Mutation rewiring degron network	0.2778
p.P354Q	DO47578	SKCM	ICGC	DADTGE	DEG_Kelch_Keap1_1	347:352	Mutation rewiring degron network	0.2778
p.P345S	TCGA-K4-A5RI	BLCA	TCGA	DADTGE	DEG_Kelch_Keap1_1	347:352	Mutation rewiring degron network	0.2778
p.N338K	DO229009	LICA	ICGC	DADTGE	DEG_Kelch_Keap1_1	347:352	Mutation rewiring degron network	0.0833
p.Y337C	ACH-000530	Lung Cancer	CCLE	DADTGE	DEG_Kelch_Keap1_1	347:352	Mutation rewiring degron network	0.0556
p.Y337C	DMS-114	lung	COSMIC	DADTGE	DEG_Kelch_Keap1_1	347:352	Mutation rewiring degron network	0.0556
p.L354Q	ACH-000969	Colon/Colorectal Cancer	CCLE	DADTGE	DEG_Kelch_Keap1_1	347:352	Mutation rewiring degron network	0.2778
p.L354Q	KM12	large intestine	COSMIC	DADTGE	DEG_Kelch_Keap1_1	347:352	Mutation rewiring degron network	0.2778
p.V342L	ACH-002132	Lung Cancer	CCLE	DADTGE	DEG_Kelch_Keap1_1	347:352	Mutation rewiring degron network	0.1944
p.V342L	H2804	pleura	COSMIC	DADTGE	DEG_Kelch_Keap1_1	347:352	Mutation rewiring degron network	0.1944
p.R352Q	ESS-1	endometrium	COSMIC	DADTGE	DEG_Kelch_Keap1_1	347:352	Mutation altering degron motif	0.7329
p.A355V	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	DADTGE	DEG_Kelch_Keap1_1	347:352	Mutation rewiring degron network	0.25

Kaplan plot for RTKN in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RTKN

UniProt ID: Q9BST9

Entrez ID: 6242

Protein name: Rhotekin

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RTKN in