DegronMD

Uniprot ID: Q9BST9

Source protein: Rhotekin

Source gene: RTKN

Class: DEG_Kelch_Keap1_1

Location: 347:352

E3 ligase: KEAP1

DEGRON score: 0.6981

ASA_SCORE: 77.55

COIL: 0.8112

CONS_SCORE: 0.4766

DSS_SCORE: 0.3545

HELIX: 0.1527

FCONS_SCORE: 0.9221

RIG_SCORE: 0.734

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E346K	TCGA-AC-A23H	BRCA	TCGA	DADTGE	DEG_Kelch_Keap1_1	0.3056
p.E346K	DO2401	BRCA	ICGC	DADTGE	DEG_Kelch_Keap1_1	0.3056
p.P345H	TCGA-AX-A1C4	UCEC	TCGA	DADTGE	DEG_Kelch_Keap1_1	0.2778
p.P345H	TCGA-D3-A2JP	SKCM	TCGA	DADTGE	DEG_Kelch_Keap1_1	0.2778
p.P345H	DO47407	SKCM	ICGC	DADTGE	DEG_Kelch_Keap1_1	0.2778
p.P345H	DO42480	UCEC	ICGC	DADTGE	DEG_Kelch_Keap1_1	0.2778
p.P354Q	TCGA-D3-A2JC	SKCM	TCGA	DADTGE	DEG_Kelch_Keap1_1	0.2778
p.P354Q	DO47578	SKCM	ICGC	DADTGE	DEG_Kelch_Keap1_1	0.2778
p.P345S	TCGA-K4-A5RI	BLCA	TCGA	DADTGE	DEG_Kelch_Keap1_1	0.2778
p.N338K	DO229009	LICA	ICGC	DADTGE	DEG_Kelch_Keap1_1	0.0833
p.Y337C	ACH-000530	Lung Cancer	CCLE	DADTGE	DEG_Kelch_Keap1_1	0.0556
p.Y337C	DMS-114	lung	COSMIC	DADTGE	DEG_Kelch_Keap1_1	0.0556
p.L354Q	ACH-000969	Colon/Colorectal Cancer	CCLE	DADTGE	DEG_Kelch_Keap1_1	0.2778
p.L354Q	KM12	large_intestine	COSMIC	DADTGE	DEG_Kelch_Keap1_1	0.2778
p.V342L	ACH-002132	Lung Cancer	CCLE	DADTGE	DEG_Kelch_Keap1_1	0.1944
p.V342L	H2804	pleura	COSMIC	DADTGE	DEG_Kelch_Keap1_1	0.1944
p.R352Q	ESS-1	endometrium	COSMIC	DADTGE	DEG_Kelch_Keap1_1	0.7329
p.A355V	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	DADTGE	DEG_Kelch_Keap1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BST9	Rhotekin	DEG_Kelch_Keap1_1	347:352	DADTGE	KEAP1	0.6981	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons