DegronMD - Q9BT17(MTG1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R325W	TCGA-50-6590	LUAD	TCGA	RRGLLGSVM	DEG_APCC_DBOX_1	310:318	Mutation rewiring degron network	0.1389
p.R325W	DO222769	COCA	ICGC	RRGLLGSVM	DEG_APCC_DBOX_1	310:318	Mutation rewiring degron network	0.1389
p.R325W	DO24692	LUAD	ICGC	RRGLLGSVM	DEG_APCC_DBOX_1	310:318	Mutation rewiring degron network	0.1389
p.L321P	TCGA-AP-A1DK	UCEC	TCGA	RRGLLGSVM	DEG_APCC_DBOX_1	310:318	Mutation rewiring degron network	0.25
p.L321P	DO42033	UCEC	ICGC	RRGLLGSVM	DEG_APCC_DBOX_1	310:318	Mutation rewiring degron network	0.25
p.R311C	TCGA-AU-6004	COAD	TCGA	RRGLLGSVM	DEG_APCC_DBOX_1	310:318	Mutation altering degron motif	0.8301
p.R311C	DO7780	COAD	ICGC	RRGLLGSVM	DEG_APCC_DBOX_1	310:318	Mutation altering degron motif	0.8301
p.S316F	TCGA-B5-A0JY	UCEC	TCGA	RRGLLGSVM	DEG_APCC_DBOX_1	310:318	Mutation altering degron motif	0.6871
p.S316F	DO43041	UCEC	ICGC	RRGLLGSVM	DEG_APCC_DBOX_1	310:318	Mutation altering degron motif	0.6871
p.D322N	TCGA-B5-A1MR	UCEC	TCGA	RRGLLGSVM	DEG_APCC_DBOX_1	310:318	Mutation rewiring degron network	0.2222
p.D322N	TCGA-BS-A0UV	UCEC	TCGA	RRGLLGSVM	DEG_APCC_DBOX_1	310:318	Mutation rewiring degron network	0.2222
p.D322N	TCGA-D1-A15X	UCEC	TCGA	RRGLLGSVM	DEG_APCC_DBOX_1	310:318	Mutation rewiring degron network	0.2222
p.D322N	DO43274	UCEC	ICGC	RRGLLGSVM	DEG_APCC_DBOX_1	310:318	Mutation rewiring degron network	0.2222
p.D322N	DO41758	UCEC	ICGC	RRGLLGSVM	DEG_APCC_DBOX_1	310:318	Mutation rewiring degron network	0.2222
p.D322N	DO42793	UCEC	ICGC	RRGLLGSVM	DEG_APCC_DBOX_1	310:318	Mutation rewiring degron network	0.2222
p.A300V	DO222574	BTCA	ICGC	RRGLLGSVM	DEG_APCC_DBOX_1	310:318	Mutation rewiring degron network	0.0556
p.V317M	DO52528	EOPC	ICGC	RRGLLGSVM	DEG_APCC_DBOX_1	310:318	Mutation altering degron motif	0.6097
p.V317L	DO228359	LICA	ICGC	RRGLLGSVM	DEG_APCC_DBOX_1	310:318	Mutation altering degron motif	0.5654
p.Q307K	DO52677	MALY	ICGC	RRGLLGSVM	DEG_APCC_DBOX_1	310:318	Mutation rewiring degron network	0.25
p.R311H	SIDM01609	Endometrial Carcinoma	GDSC	RRGLLGSVM	DEG_APCC_DBOX_1	310:318	Mutation altering degron motif	0.8244
p.R325Q	SIDM01609	Endometrial Carcinoma	GDSC	RRGLLGSVM	DEG_APCC_DBOX_1	310:318	Mutation rewiring degron network	0.1389

Kaplan plot for MTG1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MTG1

UniProt ID: Q9BT17

Entrez ID: 92170

Protein name: Mitochondrial ribosome-associated GTPase 1 (GTP-binding protein 7) (Mitochondrial GTPase 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MTG1 in