DegronMD

Uniprot ID: Q9BT17

Source protein: Mitochondrial ribosome-associated GTPase 1

Source gene: MTG1

Class: DEG_APCC_DBOX_1

Location: 310:318

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6068

ASA_SCORE: 42.9556

COIL: 0.6069

CONS_SCORE: 0.5924

DSS_SCORE: 0.0852

HELIX: 0.155

FCONS_SCORE: 1.4102

RIG_SCORE: 0.8054

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R325W	TCGA-50-6590	LUAD	TCGA	RRGLLGSVM	DEG_APCC_DBOX_1	0.1389
p.R325W	DO222769	COCA	ICGC	RRGLLGSVM	DEG_APCC_DBOX_1	0.1389
p.R325W	DO24692	LUAD	ICGC	RRGLLGSVM	DEG_APCC_DBOX_1	0.1389
p.L321P	TCGA-AP-A1DK	UCEC	TCGA	RRGLLGSVM	DEG_APCC_DBOX_1	0.25
p.L321P	DO42033	UCEC	ICGC	RRGLLGSVM	DEG_APCC_DBOX_1	0.25
p.R311C	TCGA-AU-6004	COAD	TCGA	RRGLLGSVM	DEG_APCC_DBOX_1	0.8301
p.R311C	DO7780	COAD	ICGC	RRGLLGSVM	DEG_APCC_DBOX_1	0.8301
p.S316F	TCGA-B5-A0JY	UCEC	TCGA	RRGLLGSVM	DEG_APCC_DBOX_1	0.6871
p.S316F	DO43041	UCEC	ICGC	RRGLLGSVM	DEG_APCC_DBOX_1	0.6871
p.D322N	TCGA-B5-A1MR	UCEC	TCGA	RRGLLGSVM	DEG_APCC_DBOX_1	0.2222
p.D322N	TCGA-BS-A0UV	UCEC	TCGA	RRGLLGSVM	DEG_APCC_DBOX_1	0.2222
p.D322N	TCGA-D1-A15X	UCEC	TCGA	RRGLLGSVM	DEG_APCC_DBOX_1	0.2222
p.D322N	DO43274	UCEC	ICGC	RRGLLGSVM	DEG_APCC_DBOX_1	0.2222
p.D322N	DO41758	UCEC	ICGC	RRGLLGSVM	DEG_APCC_DBOX_1	0.2222
p.D322N	DO42793	UCEC	ICGC	RRGLLGSVM	DEG_APCC_DBOX_1	0.2222
p.A300V	DO222574	BTCA	ICGC	RRGLLGSVM	DEG_APCC_DBOX_1	0.0556
p.V317M	DO52528	EOPC	ICGC	RRGLLGSVM	DEG_APCC_DBOX_1	0.6097
p.V317L	DO228359	LICA	ICGC	RRGLLGSVM	DEG_APCC_DBOX_1	0.5654
p.Q307K	DO52677	MALY	ICGC	RRGLLGSVM	DEG_APCC_DBOX_1	0.25
p.R311H	SIDM01609	Endometrial Carcinoma	GDSC	RRGLLGSVM	DEG_APCC_DBOX_1	0.8244
p.R325Q	SIDM01609	Endometrial Carcinoma	GDSC	RRGLLGSVM	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BT17	Mitochondrial ribosome-associated GTPase 1	DEG_APCC_DBOX_1	310:318	RRGLLGSVM	APC,CDC20,FZR1	0.6068	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons