DegronMD - Q9BTE6(AARSD1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A138V	TCGA-B5-A3FC	UCEC	TCGA	LDTPSMT	DEG_SCF_FBW7_1	141:147	Mutation rewiring degron network	0.25
p.A138V	DO41871	UCEC	ICGC	LDTPSMT	DEG_SCF_FBW7_1	141:147	Mutation rewiring degron network	0.25
p.A138V	ACH-000999	Colon/Colorectal Cancer	CCLE	LDTPSMT	DEG_SCF_FBW7_1	141:147	Mutation rewiring degron network	0.25
p.A138V	SNU-1040	large intestine	COSMIC	LDTPSMT	DEG_SCF_FBW7_1	141:147	Mutation rewiring degron network	0.25
p.A153V	TCGA-BR-A4QL	STAD	TCGA	LDTPSMT	DEG_SCF_FBW7_1	141:147	Mutation rewiring degron network	0.1667
p.A153V	DO38723	STAD	ICGC	LDTPSMT	DEG_SCF_FBW7_1	141:147	Mutation rewiring degron network	0.1667
p.G133V	TCGA-D3-A2J6	SKCM	TCGA	LDTPSMT	DEG_SCF_FBW7_1	141:147	Mutation rewiring degron network	0.1111
p.G133V	DO37901	SKCM	ICGC	LDTPSMT	DEG_SCF_FBW7_1	141:147	Mutation rewiring degron network	0.1111
p.R134K	TCGA-EA-A5FO	CESC	TCGA	LDTPSMT	DEG_SCF_FBW7_1	141:147	Mutation rewiring degron network	0.1389
p.R134K	DO48994	CESC	ICGC	LDTPSMT	DEG_SCF_FBW7_1	141:147	Mutation rewiring degron network	0.1389
p.T147A	TCGA-HR-A2OH	SKCM	TCGA	LDTPSMT	DEG_SCF_FBW7_1	141:147	Mutation altering degron motif	0.7139
p.T147A	DO37774	SKCM	ICGC	LDTPSMT	DEG_SCF_FBW7_1	141:147	Mutation altering degron motif	0.7139
p.P144L	TCGA-W3-AA1O	SKCM	TCGA	LDTPSMT	DEG_SCF_FBW7_1	141:147	Mutation altering degron motif	0.7582
p.P144L	DO51274	SKCM	ICGC	LDTPSMT	DEG_SCF_FBW7_1	141:147	Mutation altering degron motif	0.7582
p.P144S	TCGA-W3-AA1O	SKCM	TCGA	LDTPSMT	DEG_SCF_FBW7_1	141:147	Mutation altering degron motif	0.6752
p.P144S	DO51274	SKCM	ICGC	LDTPSMT	DEG_SCF_FBW7_1	141:147	Mutation altering degron motif	0.6752
p.S144F	DO4683	BRCA	ICGC	LDTPSMT	DEG_SCF_FBW7_1	141:147	Mutation altering degron motif	0.7982
p.D152V	DO51650	CESC	ICGC	LDTPSMT	DEG_SCF_FBW7_1	141:147	Mutation rewiring degron network	0.1944
p.P131Q	DO229022	LICA	ICGC	LDTPSMT	DEG_SCF_FBW7_1	141:147	Mutation rewiring degron network	0.0556
p.T134N	DO229036	LICA	ICGC	LDTPSMT	DEG_SCF_FBW7_1	141:147	Mutation rewiring degron network	0.1389
p.A138G	DO23366	LINC	ICGC	LDTPSMT	DEG_SCF_FBW7_1	141:147	Mutation rewiring degron network	0.25
p.E149Q	ACH-000478	Liver Cancer	CCLE	LDTPSMT	DEG_SCF_FBW7_1	141:147	Mutation rewiring degron network	0.2778
p.E149Q	SNU-387	liver	COSMIC	LDTPSMT	DEG_SCF_FBW7_1	141:147	Mutation rewiring degron network	0.2778
p.I154F	ACH-002285	Neuroblastoma	CCLE	LDTPSMT	DEG_SCF_FBW7_1	141:147	Mutation rewiring degron network	0.1389
p.I154F	NB7	autonomic ganglia	COSMIC	LDTPSMT	DEG_SCF_FBW7_1	141:147	Mutation rewiring degron network	0.1389

Kaplan plot for AARSD1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AARSD1

UniProt ID: Q9BTE6

Entrez ID: 100885850

Protein name: Alanyl-tRNA editing protein Aarsd1 (Alanyl-tRNA synthetase domain-containing protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AARSD1 in