DegronMD

Uniprot ID: Q9BTE6

Source protein: Alanyl-tRNA editing protein Aarsd1

Source gene: AARSD1

Class: DEG_SCF_FBW7_1

Location: 141:147

E3 ligase: FBXW7

DEGRON score: 0.9923

ASA_SCORE: 56.6571

COIL: 0.851

CONS_SCORE: 0.4597

DSS_SCORE: 0.3328

HELIX: 0.0194

FCONS_SCORE: 0.9281

RIG_SCORE: 0.7605

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A138V	TCGA-B5-A3FC	UCEC	TCGA	LDTPSMT	DEG_SCF_FBW7_1	0.25
p.A138V	DO41871	UCEC	ICGC	LDTPSMT	DEG_SCF_FBW7_1	0.25
p.A138V	ACH-000999	Colon/Colorectal Cancer	CCLE	LDTPSMT	DEG_SCF_FBW7_1	0.25
p.A138V	SNU-1040	large_intestine	COSMIC	LDTPSMT	DEG_SCF_FBW7_1	0.25
p.A153V	TCGA-BR-A4QL	STAD	TCGA	LDTPSMT	DEG_SCF_FBW7_1	0.1667
p.A153V	DO38723	STAD	ICGC	LDTPSMT	DEG_SCF_FBW7_1	0.1667
p.G133V	TCGA-D3-A2J6	SKCM	TCGA	LDTPSMT	DEG_SCF_FBW7_1	0.1111
p.G133V	DO37901	SKCM	ICGC	LDTPSMT	DEG_SCF_FBW7_1	0.1111
p.R134K	TCGA-EA-A5FO	CESC	TCGA	LDTPSMT	DEG_SCF_FBW7_1	0.1389
p.R134K	DO48994	CESC	ICGC	LDTPSMT	DEG_SCF_FBW7_1	0.1389
p.T147A	TCGA-HR-A2OH	SKCM	TCGA	LDTPSMT	DEG_SCF_FBW7_1	0.7139
p.T147A	DO37774	SKCM	ICGC	LDTPSMT	DEG_SCF_FBW7_1	0.7139
p.P144L	TCGA-W3-AA1O	SKCM	TCGA	LDTPSMT	DEG_SCF_FBW7_1	0.7582
p.P144L	DO51274	SKCM	ICGC	LDTPSMT	DEG_SCF_FBW7_1	0.7582
p.P144S	TCGA-W3-AA1O	SKCM	TCGA	LDTPSMT	DEG_SCF_FBW7_1	0.6752
p.P144S	DO51274	SKCM	ICGC	LDTPSMT	DEG_SCF_FBW7_1	0.6752
p.S144F	DO4683	BRCA	ICGC	LDTPSMT	DEG_SCF_FBW7_1	0.7982
p.D152V	DO51650	CESC	ICGC	LDTPSMT	DEG_SCF_FBW7_1	0.1944
p.P131Q	DO229022	LICA	ICGC	LDTPSMT	DEG_SCF_FBW7_1	0.0556
p.T134N	DO229036	LICA	ICGC	LDTPSMT	DEG_SCF_FBW7_1	0.1389
p.A138G	DO23366	LINC	ICGC	LDTPSMT	DEG_SCF_FBW7_1	0.25
p.E149Q	ACH-000478	Liver Cancer	CCLE	LDTPSMT	DEG_SCF_FBW7_1	0.2778
p.E149Q	SNU-387	liver	COSMIC	LDTPSMT	DEG_SCF_FBW7_1	0.2778
p.I154F	ACH-002285	Neuroblastoma	CCLE	LDTPSMT	DEG_SCF_FBW7_1	0.1389
p.I154F	NB7	autonomic_ganglia	COSMIC	LDTPSMT	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BTE6	Alanyl-tRNA editing protein Aarsd1	DEG_SCF_FBW7_1	141:147	LDTPSMT	FBXW7	0.9923	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons