DegronMD - Q9BTX1(NDC1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G448V	TCGA-55-8506	LUAD	TCGA	PFGTPFGS	DEG_SCF_FBW7_1	446:453	Mutation altering degron motif	0.6421
p.G448V	DO45390	LUAD	ICGC	PFGTPFGS	DEG_SCF_FBW7_1	446:453	Mutation altering degron motif	0.6421
p.A460S	TCGA-95-7562	LUAD	TCGA	PFGTPFGS	DEG_SCF_FBW7_1	446:453	Mutation rewiring degron network	0.1389
p.A460S	DO51196	LUAD	ICGC	PFGTPFGS	DEG_SCF_FBW7_1	446:453	Mutation rewiring degron network	0.1389
p.R458Q	TCGA-B5-A11E	UCEC	TCGA	PFGTPFGS	DEG_SCF_FBW7_1	446:453	Mutation rewiring degron network	0.1944
p.R458Q	TCGA-B5-A3FC	UCEC	TCGA	PFGTPFGS	DEG_SCF_FBW7_1	446:453	Mutation rewiring degron network	0.1944
p.R458Q	DO233115	GACA	ICGC	PFGTPFGS	DEG_SCF_FBW7_1	446:453	Mutation rewiring degron network	0.1944
p.R458Q	DO41644	UCEC	ICGC	PFGTPFGS	DEG_SCF_FBW7_1	446:453	Mutation rewiring degron network	0.1944
p.R458Q	DO41871	UCEC	ICGC	PFGTPFGS	DEG_SCF_FBW7_1	446:453	Mutation rewiring degron network	0.1944
p.G448W	TCGA-D3-A3CE	SKCM	TCGA	PFGTPFGS	DEG_SCF_FBW7_1	446:453	Mutation altering degron motif	0.6714
p.G448W	DO37405	SKCM	ICGC	PFGTPFGS	DEG_SCF_FBW7_1	446:453	Mutation altering degron motif	0.6714
p.L438S	DO233918	GACA	ICGC	PFGTPFGS	DEG_SCF_FBW7_1	446:453	Mutation rewiring degron network	0.1111
p.L438V	DO50836	LICA	ICGC	PFGTPFGS	DEG_SCF_FBW7_1	446:453	Mutation rewiring degron network	0.1111
p.V455E	DO31150	OV	ICGC	PFGTPFGS	DEG_SCF_FBW7_1	446:453	Mutation rewiring degron network	0.2778
p.T440A	ACH-000982	Colon/Colorectal Cancer	CCLE	PFGTPFGS	DEG_SCF_FBW7_1	446:453	Mutation blocking phosphorylation signal	0.6111
p.A460T	ACH-001509	Head and Neck Cancer	CCLE	PFGTPFGS	DEG_SCF_FBW7_1	446:453	Mutation rewiring degron network	0.1389

Kaplan plot for NDC1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NDC1

UniProt ID: Q9BTX1

Entrez ID: 55706

Protein name: Nucleoporin NDC1 (hNDC1) (Transmembrane protein 48)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NDC1 in