DegronMD

Uniprot ID: Q9BTX1

Source protein: Nucleoporin NDC1

Source gene: NDC1

Class: DEG_SCF_FBW7_1

Location: 446:453

E3 ligase: FBXW7

DEGRON score: 0.9963

ASA_SCORE: 56.55

COIL: 0.8703

CONS_SCORE: 0.313

DSS_SCORE: 0.2929

HELIX: 0.0529

FCONS_SCORE: 1.1228

RIG_SCORE: 0.7265

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G448V	TCGA-55-8506	LUAD	TCGA	PFGTPFGS	DEG_SCF_FBW7_1	0.6421
p.G448V	DO45390	LUAD	ICGC	PFGTPFGS	DEG_SCF_FBW7_1	0.6421
p.A460S	TCGA-95-7562	LUAD	TCGA	PFGTPFGS	DEG_SCF_FBW7_1	0.1389
p.A460S	DO51196	LUAD	ICGC	PFGTPFGS	DEG_SCF_FBW7_1	0.1389
p.R458Q	TCGA-B5-A11E	UCEC	TCGA	PFGTPFGS	DEG_SCF_FBW7_1	0.1944
p.R458Q	TCGA-B5-A3FC	UCEC	TCGA	PFGTPFGS	DEG_SCF_FBW7_1	0.1944
p.R458Q	DO233115	GACA	ICGC	PFGTPFGS	DEG_SCF_FBW7_1	0.1944
p.R458Q	DO41644	UCEC	ICGC	PFGTPFGS	DEG_SCF_FBW7_1	0.1944
p.R458Q	DO41871	UCEC	ICGC	PFGTPFGS	DEG_SCF_FBW7_1	0.1944
p.G448W	TCGA-D3-A3CE	SKCM	TCGA	PFGTPFGS	DEG_SCF_FBW7_1	0.6714
p.G448W	DO37405	SKCM	ICGC	PFGTPFGS	DEG_SCF_FBW7_1	0.6714
p.L438S	DO233918	GACA	ICGC	PFGTPFGS	DEG_SCF_FBW7_1	0.1111
p.L438V	DO50836	LICA	ICGC	PFGTPFGS	DEG_SCF_FBW7_1	0.1111
p.V455E	DO31150	OV	ICGC	PFGTPFGS	DEG_SCF_FBW7_1	0.2778
p.T440A	ACH-000982	Colon/Colorectal Cancer	CCLE	PFGTPFGS	DEG_SCF_FBW7_1	0.6111
p.A460T	ACH-001509	Head and Neck Cancer	CCLE	PFGTPFGS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BTX1	Nucleoporin NDC1	DEG_SCF_FBW7_1	446:453	PFGTPFGS	FBXW7	0.9963	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons