DegronMD - Q9BU02(THTPA)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E85K	TCGA-D8-A1J8	BRCA	TCGA	LGPHTE	LIG_APCC_ABBA_1	73:78	Mutation rewiring degron network	0.1389
p.E85K	DO1269	BRCA	ICGC	LGPHTE	LIG_APCC_ABBA_1	73:78	Mutation rewiring degron network	0.1389
p.A84T	TCGA-DU-6392	LGG	TCGA	LGPHTE	LIG_APCC_ABBA_1	73:78	Mutation rewiring degron network	0.1667
p.A84T	DO22237	LGG	ICGC	LGPHTE	LIG_APCC_ABBA_1	73:78	Mutation rewiring degron network	0.1667
p.H76N	TCGA-ER-A19B	SKCM	TCGA	LGPHTE	LIG_APCC_ABBA_1	73:78	Mutation altering degron motif	0.7423
p.H76N	DO47491	SKCM	ICGC	LGPHTE	LIG_APCC_ABBA_1	73:78	Mutation altering degron motif	0.7423
p.K65R	TCGA-G9-6366	PRAD	TCGA	LGPHTE	LIG_APCC_ABBA_1	73:78	Mutation blocking ubiquitination signal	0.5556
p.K65R	DO36313	PRAD	ICGC	LGPHTE	LIG_APCC_ABBA_1	73:78	Mutation blocking ubiquitination signal	0.5556
p.G68V	TCGA-NJ-A4YQ	LUAD	TCGA	LGPHTE	LIG_APCC_ABBA_1	73:78	Mutation rewiring degron network	0.1944
p.G68V	DO218944	LUAD	ICGC	LGPHTE	LIG_APCC_ABBA_1	73:78	Mutation rewiring degron network	0.1944
p.E63D	DO229015	LICA	ICGC	LGPHTE	LIG_APCC_ABBA_1	73:78	Mutation rewiring degron network	0.0556

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons