DegronMD

Uniprot ID: Q9BU02

Source protein: Thiamine-triphosphatase

Source gene: THTPA

Class: LIG_APCC_ABBA_1

Location: 73:78

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6241

ASA_SCORE: 71.3

COIL: 0.4868

CONS_SCORE: 0.4015

DSS_SCORE: 0.3551

HELIX: 0.0297

FCONS_SCORE: 0.6863

RIG_SCORE: 0.727

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E85K	TCGA-D8-A1J8	BRCA	TCGA	LGPHTE	LIG_APCC_ABBA_1	0.1389
p.E85K	DO1269	BRCA	ICGC	LGPHTE	LIG_APCC_ABBA_1	0.1389
p.A84T	TCGA-DU-6392	LGG	TCGA	LGPHTE	LIG_APCC_ABBA_1	0.1667
p.A84T	DO22237	LGG	ICGC	LGPHTE	LIG_APCC_ABBA_1	0.1667
p.H76N	TCGA-ER-A19B	SKCM	TCGA	LGPHTE	LIG_APCC_ABBA_1	0.7423
p.H76N	DO47491	SKCM	ICGC	LGPHTE	LIG_APCC_ABBA_1	0.7423
p.K65R	TCGA-G9-6366	PRAD	TCGA	LGPHTE	LIG_APCC_ABBA_1	0.5556
p.K65R	DO36313	PRAD	ICGC	LGPHTE	LIG_APCC_ABBA_1	0.5556
p.G68V	TCGA-NJ-A4YQ	LUAD	TCGA	LGPHTE	LIG_APCC_ABBA_1	0.1944
p.G68V	DO218944	LUAD	ICGC	LGPHTE	LIG_APCC_ABBA_1	0.1944
p.E63D	DO229015	LICA	ICGC	LGPHTE	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BU02	Thiamine-triphosphatase	LIG_APCC_ABBA_1	73:78	LGPHTE	APC,CDC20,FZR1	0.6241	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons