DegronMD - Q9BU64(CENPO)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K51M	TCGA-23-2079	OV	TCGA	LRDELRAVV	DEG_APCC_DBOX_1	58:66	Mutation blocking ubiquitination signal	0.5833
p.K51M	DO27999	OV	ICGC	LRDELRAVV	DEG_APCC_DBOX_1	58:66	Mutation blocking ubiquitination signal	0.5833
p.R57C	TCGA-2W-A8YY	CESC	TCGA	LRDELRAVV	DEG_APCC_DBOX_1	58:66	Mutation rewiring degron network	0.3056
p.R57C	DO223732	CESC	ICGC	LRDELRAVV	DEG_APCC_DBOX_1	58:66	Mutation rewiring degron network	0.3056
p.R57C	DO227976	COCA	ICGC	LRDELRAVV	DEG_APCC_DBOX_1	58:66	Mutation rewiring degron network	0.3056
p.V73A	TCGA-D8-A1XQ	BRCA	TCGA	LRDELRAVV	DEG_APCC_DBOX_1	58:66	Mutation rewiring degron network	0.1389
p.V73A	DO3095	BRCA	ICGC	LRDELRAVV	DEG_APCC_DBOX_1	58:66	Mutation rewiring degron network	0.1389
p.R59Q	TCGA-EO-A22X	UCEC	TCGA	LRDELRAVV	DEG_APCC_DBOX_1	58:66	Mutation altering degron motif	0.7329
p.R59Q	DO43907	UCEC	ICGC	LRDELRAVV	DEG_APCC_DBOX_1	58:66	Mutation altering degron motif	0.7329
p.G49V	TCGA-ZJ-AAXU	CESC	TCGA	LRDELRAVV	DEG_APCC_DBOX_1	58:66	Mutation rewiring degron network	0.0833
p.G49V	DO219759	CESC	ICGC	LRDELRAVV	DEG_APCC_DBOX_1	58:66	Mutation rewiring degron network	0.0833
p.H53N	DO222762	COCA	ICGC	LRDELRAVV	DEG_APCC_DBOX_1	58:66	Mutation rewiring degron network	0.1944
p.R57L	DO228976	LICA	ICGC	LRDELRAVV	DEG_APCC_DBOX_1	58:66	Mutation rewiring degron network	0.3056
p.R57H	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	LRDELRAVV	DEG_APCC_DBOX_1	58:66	Mutation rewiring degron network	0.3056
p.R57H	SIDM00498	Colorectal Carcinoma	GDSC	LRDELRAVV	DEG_APCC_DBOX_1	58:66	Mutation rewiring degron network	0.3056
p.R57H	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	LRDELRAVV	DEG_APCC_DBOX_1	58:66	Mutation rewiring degron network	0.3056
p.R57H	SNU-C5	large intestine	COSMIC	LRDELRAVV	DEG_APCC_DBOX_1	58:66	Mutation rewiring degron network	0.3056
p.R67W	ACH-000973	Bladder Cancer	CCLE	LRDELRAVV	DEG_APCC_DBOX_1	58:66	Mutation rewiring degron network	0.3056
p.R51H	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	LRDELRAVV	DEG_APCC_DBOX_1	58:66	Mutation blocking ubiquitination signal	0.5833
p.R51H	SNU-C5	large intestine	COSMIC	LRDELRAVV	DEG_APCC_DBOX_1	58:66	Mutation blocking ubiquitination signal	0.5833

Kaplan plot for CENPO in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CENPO

UniProt ID: Q9BU64

Entrez ID: 79172

Protein name: Centromere protein O (CENP-O) (Interphase centromere complex protein 36)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CENPO in