DegronMD

Uniprot ID: Q9BU64

Source protein: Centromere protein O

Source gene: CENPO

Class: DEG_APCC_DBOX_1

Location: 58:66

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6509

ASA_SCORE: 73.8889

COIL: 0.0233

CONS_SCORE: 0.5211

DSS_SCORE: 0.3076

HELIX: 0.9763

FCONS_SCORE: 1.3488

RIG_SCORE: 0.8153

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K51M	TCGA-23-2079	OV	TCGA	LRDELRAVV	DEG_APCC_DBOX_1	0.5833
p.K51M	DO27999	OV	ICGC	LRDELRAVV	DEG_APCC_DBOX_1	0.5833
p.R57C	TCGA-2W-A8YY	CESC	TCGA	LRDELRAVV	DEG_APCC_DBOX_1	0.3056
p.R57C	DO223732	CESC	ICGC	LRDELRAVV	DEG_APCC_DBOX_1	0.3056
p.R57C	DO227976	COCA	ICGC	LRDELRAVV	DEG_APCC_DBOX_1	0.3056
p.V73A	TCGA-D8-A1XQ	BRCA	TCGA	LRDELRAVV	DEG_APCC_DBOX_1	0.1389
p.V73A	DO3095	BRCA	ICGC	LRDELRAVV	DEG_APCC_DBOX_1	0.1389
p.R59Q	TCGA-EO-A22X	UCEC	TCGA	LRDELRAVV	DEG_APCC_DBOX_1	0.7329
p.R59Q	DO43907	UCEC	ICGC	LRDELRAVV	DEG_APCC_DBOX_1	0.7329
p.G49V	TCGA-ZJ-AAXU	CESC	TCGA	LRDELRAVV	DEG_APCC_DBOX_1	0.0833
p.G49V	DO219759	CESC	ICGC	LRDELRAVV	DEG_APCC_DBOX_1	0.0833
p.H53N	DO222762	COCA	ICGC	LRDELRAVV	DEG_APCC_DBOX_1	0.1944
p.R57L	DO228976	LICA	ICGC	LRDELRAVV	DEG_APCC_DBOX_1	0.3056
p.R57H	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	LRDELRAVV	DEG_APCC_DBOX_1	0.3056
p.R57H	SIDM00498	Colorectal Carcinoma	GDSC	LRDELRAVV	DEG_APCC_DBOX_1	0.3056
p.R57H	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	LRDELRAVV	DEG_APCC_DBOX_1	0.3056
p.R57H	SNU-C5	large_intestine	COSMIC	LRDELRAVV	DEG_APCC_DBOX_1	0.3056
p.R67W	ACH-000973	Bladder Cancer	CCLE	LRDELRAVV	DEG_APCC_DBOX_1	0.3056
p.R51H	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	LRDELRAVV	DEG_APCC_DBOX_1	0.5833
p.R51H	SNU-C5	large_intestine	COSMIC	LRDELRAVV	DEG_APCC_DBOX_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BU64	Centromere protein O	DEG_APCC_DBOX_1	58:66	LRDELRAVV	APC,CDC20,FZR1	0.6509	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons