DegronMD - Q9BUB7(TMEM70)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P72H	TCGA-D3-A2JP	SKCM	TCGA	IPVYWE	LIG_APCC_ABBA_1	71:76	Mutation altering degron motif	0.6583
p.P72H	DO47407	SKCM	ICGC	IPVYWE	LIG_APCC_ABBA_1	71:76	Mutation altering degron motif	0.6583
p.P85Q	DO222755	COCA	ICGC	IPVYWE	LIG_APCC_ABBA_1	71:76	Mutation rewiring degron network	0.0833
p.L62I	DO233888	GACA	ICGC	IPVYWE	LIG_APCC_ABBA_1	71:76	Mutation rewiring degron network	0.0833
p.R65L	DO229034	LICA	ICGC	IPVYWE	LIG_APCC_ABBA_1	71:76	Mutation rewiring degron network	0.1667
p.R80Q	DO222749	MELA	ICGC	IPVYWE	LIG_APCC_ABBA_1	71:76	Mutation rewiring degron network	0.2222
p.Y78C	SIDM00362	Burkitt's Lymphoma	GDSC	IPVYWE	LIG_APCC_ABBA_1	71:76	Mutation rewiring degron network	0.2778
p.Y78C	ACH-002293	Lymphoma	CCLE	IPVYWE	LIG_APCC_ABBA_1	71:76	Mutation rewiring degron network	0.2778
p.Y78C	P32-ISH	haematopoietic and lymphoid tissue	COSMIC	IPVYWE	LIG_APCC_ABBA_1	71:76	Mutation rewiring degron network	0.2778
p.R68P	ACH-000862	Bladder Cancer	CCLE	IPVYWE	LIG_APCC_ABBA_1	71:76	Mutation rewiring degron network	0.25

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons