DegronMD

Uniprot ID: Q9BUB7

Source protein: Transmembrane protein 70, mitochondrial

Source gene: TMEM70

Class: LIG_APCC_ABBA_1

Location: 71:76

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5919

ASA_SCORE: 77.1667

COIL: 0.6342

CONS_SCORE: 0.3074

DSS_SCORE: 0.1899

HELIX: 0.0627

FCONS_SCORE: 1.0008

RIG_SCORE: 0.8689

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P72H	TCGA-D3-A2JP	SKCM	TCGA	IPVYWE	LIG_APCC_ABBA_1	0.6583
p.P72H	DO47407	SKCM	ICGC	IPVYWE	LIG_APCC_ABBA_1	0.6583
p.P85Q	DO222755	COCA	ICGC	IPVYWE	LIG_APCC_ABBA_1	0.0833
p.L62I	DO233888	GACA	ICGC	IPVYWE	LIG_APCC_ABBA_1	0.0833
p.R65L	DO229034	LICA	ICGC	IPVYWE	LIG_APCC_ABBA_1	0.1667
p.R80Q	DO222749	MELA	ICGC	IPVYWE	LIG_APCC_ABBA_1	0.2222
p.Y78C	SIDM00362	Burkitt's Lymphoma	GDSC	IPVYWE	LIG_APCC_ABBA_1	0.2778
p.Y78C	ACH-002293	Lymphoma	CCLE	IPVYWE	LIG_APCC_ABBA_1	0.2778
p.Y78C	P32-ISH	haematopoietic_and_lymphoid_tissue	COSMIC	IPVYWE	LIG_APCC_ABBA_1	0.2778
p.R68P	ACH-000862	Bladder Cancer	CCLE	IPVYWE	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BUB7	Transmembrane protein 70, mitochondrial	LIG_APCC_ABBA_1	71:76	IPVYWE	APC,CDC20,FZR1	0.5919	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons