DegronMD - Q9BUF5(TUBB6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q57H	TCGA-BS-A0UF	UCEC	TCGA	PRAALVDLE	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.2222
p.Q57H	DO41488	UCEC	ICGC	PRAALVDLE	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.2222
p.G71S	TCGA-CN-6012	HNSC	TCGA	PRAALVDLE	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.2778
p.G71S	DO15743	HNSC	ICGC	PRAALVDLE	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.2778
p.P70S	TCGA-D1-A2G0	UCEC	TCGA	PRAALVDLE	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.3056
p.P70S	DO220881	MELA	ICGC	PRAALVDLE	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.3056
p.P70S	DO43049	UCEC	ICGC	PRAALVDLE	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.3056
p.M73K	TCGA-DD-AADF	LIHC	TCGA	PRAALVDLE	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.2222
p.M73K	DO52232	LIHC	ICGC	PRAALVDLE	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.2222
p.A63V	TCGA-LN-A9FQ	ESCA	TCGA	PRAALVDLE	DEG_APCC_DBOX_1	61:69	Mutation altering degron motif	0.5825
p.R77Q	TCGA-VQ-A91K	STAD	TCGA	PRAALVDLE	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.1111
p.R77Q	DO51785	STAD	ICGC	PRAALVDLE	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.1111
p.R77Q	SIDM00498	Colorectal Carcinoma	GDSC	PRAALVDLE	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.1111
p.R77Q	ACH-000970	Colon/Colorectal Cancer	CCLE	PRAALVDLE	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.1111
p.R77Q	SNU-C5	large intestine	COSMIC	PRAALVDLE	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.1111
p.S55L	TCGA-YC-A89H	BLCA	TCGA	PRAALVDLE	DEG_APCC_DBOX_1	61:69	Mutation blocking phosphorylation signal	0.6111
p.S55L	DO51948	BLCA	ICGC	PRAALVDLE	DEG_APCC_DBOX_1	61:69	Mutation blocking phosphorylation signal	0.6111
p.K58N	DO225111	BRCA	ICGC	PRAALVDLE	DEG_APCC_DBOX_1	61:69	Mutation blocking ubiquitination signal	0.6944
p.R77W	DO222574	BTCA	ICGC	PRAALVDLE	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.1111
p.V76M	DO220866	MELA	ICGC	PRAALVDLE	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.1389
p.G71C	SIDM00789	Colorectal Carcinoma	GDSC	PRAALVDLE	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.2778
p.G71C	ACH-000997	Colon/Colorectal Cancer	CCLE	PRAALVDLE	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.2778
p.G71C	ACH-001061	Colon/Colorectal Cancer	CCLE	PRAALVDLE	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.2778
p.G71C	HCT-15	large intestine	COSMIC	PRAALVDLE	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.2778
p.D74Y	ACH-000975	Lung Cancer	CCLE	PRAALVDLE	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.1944

Kaplan plot for TUBB6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TUBB6

UniProt ID: Q9BUF5

Entrez ID: 84617

Protein name: Tubulin beta-6 chain (Tubulin beta class V)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TUBB6 in