DegronMD

Uniprot ID: Q9BUF5

Source protein: Tubulin beta-6 chain

Source gene: TUBB6

Class: DEG_APCC_DBOX_1

Location: 61:69

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6042

ASA_SCORE: 28.7222

COIL: 0.5208

CONS_SCORE: 0.8943

DSS_SCORE: 0.3486

HELIX: 0.0711

FCONS_SCORE: 1.1169

RIG_SCORE: 0.7912

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q57H	TCGA-BS-A0UF	UCEC	TCGA	PRAALVDLE	DEG_APCC_DBOX_1	0.2222
p.Q57H	DO41488	UCEC	ICGC	PRAALVDLE	DEG_APCC_DBOX_1	0.2222
p.G71S	TCGA-CN-6012	HNSC	TCGA	PRAALVDLE	DEG_APCC_DBOX_1	0.2778
p.G71S	DO15743	HNSC	ICGC	PRAALVDLE	DEG_APCC_DBOX_1	0.2778
p.P70S	TCGA-D1-A2G0	UCEC	TCGA	PRAALVDLE	DEG_APCC_DBOX_1	0.3056
p.P70S	DO220881	MELA	ICGC	PRAALVDLE	DEG_APCC_DBOX_1	0.3056
p.P70S	DO43049	UCEC	ICGC	PRAALVDLE	DEG_APCC_DBOX_1	0.3056
p.M73K	TCGA-DD-AADF	LIHC	TCGA	PRAALVDLE	DEG_APCC_DBOX_1	0.2222
p.M73K	DO52232	LIHC	ICGC	PRAALVDLE	DEG_APCC_DBOX_1	0.2222
p.A63V	TCGA-LN-A9FQ	ESCA	TCGA	PRAALVDLE	DEG_APCC_DBOX_1	0.5825
p.R77Q	TCGA-VQ-A91K	STAD	TCGA	PRAALVDLE	DEG_APCC_DBOX_1	0.1111
p.R77Q	DO51785	STAD	ICGC	PRAALVDLE	DEG_APCC_DBOX_1	0.1111
p.R77Q	SIDM00498	Colorectal Carcinoma	GDSC	PRAALVDLE	DEG_APCC_DBOX_1	0.1111
p.R77Q	ACH-000970	Colon/Colorectal Cancer	CCLE	PRAALVDLE	DEG_APCC_DBOX_1	0.1111
p.R77Q	SNU-C5	large_intestine	COSMIC	PRAALVDLE	DEG_APCC_DBOX_1	0.1111
p.S55L	TCGA-YC-A89H	BLCA	TCGA	PRAALVDLE	DEG_APCC_DBOX_1	0.6111
p.S55L	DO51948	BLCA	ICGC	PRAALVDLE	DEG_APCC_DBOX_1	0.6111
p.K58N	DO225111	BRCA	ICGC	PRAALVDLE	DEG_APCC_DBOX_1	0.6944
p.R77W	DO222574	BTCA	ICGC	PRAALVDLE	DEG_APCC_DBOX_1	0.1111
p.V76M	DO220866	MELA	ICGC	PRAALVDLE	DEG_APCC_DBOX_1	0.1389
p.G71C	SIDM00789	Colorectal Carcinoma	GDSC	PRAALVDLE	DEG_APCC_DBOX_1	0.2778
p.G71C	ACH-000997	Colon/Colorectal Cancer	CCLE	PRAALVDLE	DEG_APCC_DBOX_1	0.2778
p.G71C	ACH-001061	Colon/Colorectal Cancer	CCLE	PRAALVDLE	DEG_APCC_DBOX_1	0.2778
p.G71C	HCT-15	large_intestine	COSMIC	PRAALVDLE	DEG_APCC_DBOX_1	0.2778
p.D74Y	ACH-000975	Lung Cancer	CCLE	PRAALVDLE	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BUF5	Tubulin beta-6 chain	DEG_APCC_DBOX_1	61:69	PRAALVDLE	APC,CDC20,FZR1	0.6042	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRAALVDLE

Degron related mutations and impact score

Drug responses associated with TUBB6 mutations

All proteins holding degron of PRAALVDLE