DegronMD - Q9BUL5(PHF23)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E291K	TCGA-55-6969	LUAD	TCGA	RPPATVHPE	DEG_SIAH_1	283:291	Mutation altering degron motif	0.591
p.E280D	TCGA-AX-A2HC	UCEC	TCGA	RPPATVHPE	DEG_SIAH_1	283:291	Mutation rewiring degron network	0.25
p.L291M	DO9698	COAD	ICGC	RPPATVHPE	DEG_SIAH_1	283:291	Mutation altering degron motif	0.711
p.H297R	DO233207	GACA	ICGC	RPPATVHPE	DEG_SIAH_1	283:291	Mutation rewiring degron network	0.1667
p.C277Y	DO233944	GACA	ICGC	RPPATVHPE	DEG_SIAH_1	283:291	Mutation rewiring degron network	0.1667
p.G283W	DO50458	KIRC	ICGC	RPPATVHPE	DEG_SIAH_1	283:291	Mutation altering degron motif	0.7825
p.R278L	DO50971	LICA	ICGC	RPPATVHPE	DEG_SIAH_1	283:291	Mutation rewiring degron network	0.1944
p.I287V	DO219771	UCEC	ICGC	RPPATVHPE	DEG_SIAH_1	283:291	Mutation altering degron motif	0.7076
p.R283S	SIDM00945	Colorectal Carcinoma	GDSC	RPPATVHPE	DEG_SIAH_1	283:291	Mutation altering degron motif	0.6316
p.R283S	CL-34	large intestine	COSMIC	RPPATVHPE	DEG_SIAH_1	283:291	Mutation altering degron motif	0.6316
p.P285S	SIDM00150	Colorectal Carcinoma	GDSC	RPPATVHPE	DEG_SIAH_1	283:291	Mutation altering degron motif	0.5641
p.P285S	KM12	large intestine	COSMIC	RPPATVHPE	DEG_SIAH_1	283:291	Mutation altering degron motif	0.5641
p.P281S	KM12	large intestine	COSMIC	RPPATVHPE	DEG_SIAH_1	283:291	Mutation rewiring degron network	0.2778
p.A301V	Jurkat	haematopoietic and lymphoid tissue	COSMIC	RPPATVHPE	DEG_SIAH_1	283:291	Mutation substituting flanking lysine	0.1667
p.C300S	LNCaP-Clone-FGC	prostate	COSMIC	RPPATVHPE	DEG_SIAH_1	283:291	Mutation rewiring degron network	0.0833
p.R279S	CL-34	large intestine	COSMIC	RPPATVHPE	DEG_SIAH_1	283:291	Mutation rewiring degron network	0.2222

Kaplan plot for PHF23 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PHF23

UniProt ID: Q9BUL5

Entrez ID: 79142

Protein name: PHD finger protein 23 (PDH-containing protein JUNE-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PHF23 in