DegronMD

Uniprot ID: Q9BUL5

Source protein: PHD finger protein 23

Source gene: PHF23

Class: DEG_SIAH_1

Location: 283:291

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.708

ASA_SCORE: 103.8111

COIL: 0.9428

CONS_SCORE: 0.52

DSS_SCORE: 0.8038

HELIX: 0.0237

FCONS_SCORE: 0.9759

RIG_SCORE: 0.5832

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E291K	TCGA-55-6969	LUAD	TCGA	RPPATVHPE	DEG_SIAH_1	0.591
p.E280D	TCGA-AX-A2HC	UCEC	TCGA	RPPATVHPE	DEG_SIAH_1	0.25
p.L291M	DO9698	COAD	ICGC	RPPATVHPE	DEG_SIAH_1	0.711
p.H297R	DO233207	GACA	ICGC	RPPATVHPE	DEG_SIAH_1	0.1667
p.C277Y	DO233944	GACA	ICGC	RPPATVHPE	DEG_SIAH_1	0.1667
p.G283W	DO50458	KIRC	ICGC	RPPATVHPE	DEG_SIAH_1	0.7825
p.R278L	DO50971	LICA	ICGC	RPPATVHPE	DEG_SIAH_1	0.1944
p.I287V	DO219771	UCEC	ICGC	RPPATVHPE	DEG_SIAH_1	0.7076
p.R283S	SIDM00945	Colorectal Carcinoma	GDSC	RPPATVHPE	DEG_SIAH_1	0.6316
p.R283S	CL-34	large_intestine	COSMIC	RPPATVHPE	DEG_SIAH_1	0.6316
p.P285S	SIDM00150	Colorectal Carcinoma	GDSC	RPPATVHPE	DEG_SIAH_1	0.5641
p.P285S	KM12	large_intestine	COSMIC	RPPATVHPE	DEG_SIAH_1	0.5641
p.P281S	KM12	large_intestine	COSMIC	RPPATVHPE	DEG_SIAH_1	0.2778
p.A301V	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	RPPATVHPE	DEG_SIAH_1	0.1667
p.C300S	LNCaP-Clone-FGC	prostate	COSMIC	RPPATVHPE	DEG_SIAH_1	0.0833
p.R279S	CL-34	large_intestine	COSMIC	RPPATVHPE	DEG_SIAH_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BUL5	PHD finger protein 23	DEG_SIAH_1	283:291	RPPATVHPE	SIAH1,SIAH2,SIAH3	0.708	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons