WRAP53
UniProt ID: Q9BUR4
Entrez ID: 55135
Protein name: Telomerase Cajal body protein 1 (WD repeat-containing protein 79) (WD40 repeat-containing protein antisense to TP53 gene) (WRAP53beta)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies (PubMed:29804836, PubMed:29695869). Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC) (...
FUNCTION: RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies (PubMed:29804836, PubMed:29695869). Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC) (PubMed:19285445, PubMed:20351177, PubMed:29804836, PubMed:29695869). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes (PubMed:19179534, PubMed:20351177, PubMed:26170453, PubMed:29695869). In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex (PubMed:27525486, PubMed:29804836). Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity (PubMed:29804836). In addition, also controls telomerase holoenzyme complex localization to Cajal body (PubMed:22547674). During S phase, required for delivery of TERC to telomeres during S phase and for telomerase activity (PubMed:29804836). In addition to its role in telomere maintenance, also required for Cajal body formation, probably by mediating localization of scaRNAs to Cajal bodies (PubMed:19285445, PubMed:21072240). Also plays a role in DNA repair: phosphorylated by ATM in response to DNA damage and relocalizes to sites of DNA double-strand breaks to promote the repair of DNA double-strand breaks (PubMed:25512560, PubMed:27715493). Acts by recruiting the ubiquitin ligase RNF8 to DNA breaks and promote both homologous recombination (HR) and non-homologous end joining (NHEJ) (PubMed:25512560, PubMed:27715493). {ECO:0000269|PubMed:19179534, ECO:0000269|PubMed:19285445, ECO:0000269|PubMed:20351177, ECO:0000269|PubMed:21072240, ECO:0000269|PubMed:22547674, ECO:0000269|PubMed:25512560, ECO:0000269|PubMed:26170453, ECO:0000269|PubMed:27525486, ECO:0000269|PubMed:27715493, ECO:0000269|PubMed:29695869, ECO:0000269|PubMed:29804836}.
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GO - Biological processes (BP):
Cajal body organization [GO:0030576]; DNA repair [GO:0006281]; positive regulation of DNA repair [GO:0045739]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of double-st...
Cajal body organization [GO:0030576]; DNA repair [GO:0006281]; positive regulation of DNA repair [GO:0045739]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of establishment of protein localization to telomere [GO:1904851]; positive regulation of telomerase activity [GO:0051973]; protein localization to Cajal body [GO:1904867]; RNA folding [GO:0034337]; scaRNA localization to Cajal body [GO:0090666]; telomerase RNA localization to Cajal body [GO:0090671]; telomere formation via telomerase [GO:0032203]; telomere maintenance via telomerase [GO:0007004]
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GO - Molecular function (MF):
chaperone binding [GO:0051087]; histone binding [GO:0042393]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034]; ubiquitin protein ligase binding [GO:0031625]...
chaperone binding [GO:0051087]; histone binding [GO:0042393]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034]; ubiquitin protein ligase binding [GO:0031625]
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GO - Cellular component (CC):
Cajal body [GO:0015030]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; site of double-strand break [GO:0035861]; telomerase holoenzyme complex [GO:0005697]...
Cajal body [GO:0015030]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; site of double-strand break [GO:0035861]; telomerase holoenzyme complex [GO:0005697]
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WRAP53
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Kaplan plot for WRAP53 in
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*NOTE: the Kaplan plots were collected from OncoLnc