DegronMD

Uniprot ID: Q9BUR4

Source protein: Telomerase Cajal body protein 1

Source gene: WRAP53

Class: DEG_SCF_FBW7_1

Location: 75:81

E3 ligase: FBXW7

DEGRON score: 0.9237

ASA_SCORE: 60.7714

COIL: 0.628

CONS_SCORE: 0.2402

DSS_SCORE: 0.7171

HELIX: 0.1457

FCONS_SCORE: 1.0292

RIG_SCORE: 0.6646

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S87G	TCGA-AD-5900	COAD	TCGA	LSTPLET	DEG_SCF_FBW7_1	0.6111
p.S87G	DO8514	COAD	ICGC	LSTPLET	DEG_SCF_FBW7_1	0.6111
p.L75F	TCGA-AJ-A2QM	UCEC	TCGA	LSTPLET	DEG_SCF_FBW7_1	0.6981
p.L75F	DO43690	UCEC	ICGC	LSTPLET	DEG_SCF_FBW7_1	0.6981
p.S74Y	TCGA-AP-A0LM	UCEC	TCGA	LSTPLET	DEG_SCF_FBW7_1	0.3056
p.S74Y	DO43306	UCEC	ICGC	LSTPLET	DEG_SCF_FBW7_1	0.3056
p.V73F	TCGA-AP-A1DV	UCEC	TCGA	LSTPLET	DEG_SCF_FBW7_1	0.2778
p.V73F	DO43186	UCEC	ICGC	LSTPLET	DEG_SCF_FBW7_1	0.2778
p.E80K	TCGA-EO-A3AV	UCEC	TCGA	LSTPLET	DEG_SCF_FBW7_1	0.591
p.E80K	DO52412	UCEC	ICGC	LSTPLET	DEG_SCF_FBW7_1	0.591
p.E66K	TCGA-ZF-A9RC	BLCA	TCGA	LSTPLET	DEG_SCF_FBW7_1	0.0833
p.E66K	DO219068	BLCA	ICGC	LSTPLET	DEG_SCF_FBW7_1	0.0833
p.R68G	DO230334	COCA	ICGC	LSTPLET	DEG_SCF_FBW7_1	0.1389
p.R68G	DO225404	LAML	ICGC	LSTPLET	DEG_SCF_FBW7_1	0.1389
p.L79M	DO227549	COCA	ICGC	LSTPLET	DEG_SCF_FBW7_1	0.5999
p.D71N	DO222884	COCA	ICGC	LSTPLET	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BUR4	Telomerase Cajal body protein 1	DEG_SCF_FBW7_1	75:81	LSTPLET	FBXW7	0.9237	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons