DegronMD - Q9BV35(SLC25A23)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R35C	TCGA-61-2008	OV	TCGA	LRQGLARLG	DEG_APCC_DBOX_1	34:42	Mutation altering degron motif	0.8301
p.R35C	DO29658	OV	ICGC	LRQGLARLG	DEG_APCC_DBOX_1	34:42	Mutation altering degron motif	0.8301
p.R28C	TCGA-EE-A3J8	SKCM	TCGA	LRQGLARLG	DEG_APCC_DBOX_1	34:42	Mutation rewiring degron network	0.1667
p.R28C	DO47276	SKCM	ICGC	LRQGLARLG	DEG_APCC_DBOX_1	34:42	Mutation rewiring degron network	0.1667
p.Q51K	TCGA-FS-A1Z4	SKCM	TCGA	LRQGLARLG	DEG_APCC_DBOX_1	34:42	Mutation rewiring degron network	0.0833
p.Q51K	DO37462	SKCM	ICGC	LRQGLARLG	DEG_APCC_DBOX_1	34:42	Mutation rewiring degron network	0.0833
p.G27D	TCGA-G4-6588	COAD	TCGA	LRQGLARLG	DEG_APCC_DBOX_1	34:42	Mutation rewiring degron network	0.1389
p.G27D	DO10140	COAD	ICGC	LRQGLARLG	DEG_APCC_DBOX_1	34:42	Mutation rewiring degron network	0.1389
p.Q36H	DO228483	BRCA	ICGC	LRQGLARLG	DEG_APCC_DBOX_1	34:42	Mutation altering degron motif	0.647
p.Q31K	DO229026	LICA	ICGC	LRQGLARLG	DEG_APCC_DBOX_1	34:42	Mutation rewiring degron network	0.25
p.L43F	DO222413	MELA	ICGC	LRQGLARLG	DEG_APCC_DBOX_1	34:42	Mutation rewiring degron network	0.3056
p.L43F	DO41235	UCEC	ICGC	LRQGLARLG	DEG_APCC_DBOX_1	34:42	Mutation rewiring degron network	0.3056
p.P48S	DO222638	MELA	ICGC	LRQGLARLG	DEG_APCC_DBOX_1	34:42	Mutation rewiring degron network	0.1667
p.A34D	DO51407	PRAD	ICGC	LRQGLARLG	DEG_APCC_DBOX_1	34:42	Mutation altering degron motif	0.7793
p.I42S	DO37679	SKCM	ICGC	LRQGLARLG	DEG_APCC_DBOX_1	34:42	Mutation altering degron motif	0.7341
p.R25C	DO37519	SKCM	ICGC	LRQGLARLG	DEG_APCC_DBOX_1	34:42	Mutation substituting flanking lysine	0.1944
p.L41V	SIDM00831	Head and Neck Carcinoma	GDSC	LRQGLARLG	DEG_APCC_DBOX_1	34:42	Mutation altering degron motif	0.5654
p.L41V	ACH-000207	Head and Neck Cancer	CCLE	LRQGLARLG	DEG_APCC_DBOX_1	34:42	Mutation altering degron motif	0.5654
p.L41V	Detroit562	upper aerodigestive tract	COSMIC	LRQGLARLG	DEG_APCC_DBOX_1	34:42	Mutation altering degron motif	0.5654

Kaplan plot for SLC25A23 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLC25A23

UniProt ID: Q9BV35

Entrez ID: 79085

Protein name: Calcium-binding mitochondrial carrier protein SCaMC-3 (Mitochondrial ATP-Mg/Pi carrier protein 2) (Mitochondrial Ca(2+)-dependent solute carrier protein 2) (Small calcium-binding mitochondrial carrier protein 3) (Solute carrier family 25 member 23)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLC25A23 in