DegronMD

Uniprot ID: Q9BV35

Source protein: Calcium-binding mitochondrial carrier protein SCaMC-3

Source gene: SLC25A23

Class: DEG_APCC_DBOX_1

Location: 34:42

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5654

ASA_SCORE: 57.9333

COIL: 0.2343

CONS_SCORE: 0.3153

DSS_SCORE: 0.5992

HELIX: 0.7672

FCONS_SCORE: 1.087

RIG_SCORE: 0.7009

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R35C	TCGA-61-2008	OV	TCGA	LRQGLARLG	DEG_APCC_DBOX_1	0.8301
p.R35C	DO29658	OV	ICGC	LRQGLARLG	DEG_APCC_DBOX_1	0.8301
p.R28C	TCGA-EE-A3J8	SKCM	TCGA	LRQGLARLG	DEG_APCC_DBOX_1	0.1667
p.R28C	DO47276	SKCM	ICGC	LRQGLARLG	DEG_APCC_DBOX_1	0.1667
p.Q51K	TCGA-FS-A1Z4	SKCM	TCGA	LRQGLARLG	DEG_APCC_DBOX_1	0.0833
p.Q51K	DO37462	SKCM	ICGC	LRQGLARLG	DEG_APCC_DBOX_1	0.0833
p.G27D	TCGA-G4-6588	COAD	TCGA	LRQGLARLG	DEG_APCC_DBOX_1	0.1389
p.G27D	DO10140	COAD	ICGC	LRQGLARLG	DEG_APCC_DBOX_1	0.1389
p.Q36H	DO228483	BRCA	ICGC	LRQGLARLG	DEG_APCC_DBOX_1	0.647
p.Q31K	DO229026	LICA	ICGC	LRQGLARLG	DEG_APCC_DBOX_1	0.25
p.L43F	DO222413	MELA	ICGC	LRQGLARLG	DEG_APCC_DBOX_1	0.3056
p.L43F	DO41235	UCEC	ICGC	LRQGLARLG	DEG_APCC_DBOX_1	0.3056
p.P48S	DO222638	MELA	ICGC	LRQGLARLG	DEG_APCC_DBOX_1	0.1667
p.A34D	DO51407	PRAD	ICGC	LRQGLARLG	DEG_APCC_DBOX_1	0.7793
p.I42S	DO37679	SKCM	ICGC	LRQGLARLG	DEG_APCC_DBOX_1	0.7341
p.R25C	DO37519	SKCM	ICGC	LRQGLARLG	DEG_APCC_DBOX_1	0.1944
p.L41V	SIDM00831	Head and Neck Carcinoma	GDSC	LRQGLARLG	DEG_APCC_DBOX_1	0.5654
p.L41V	ACH-000207	Head and Neck Cancer	CCLE	LRQGLARLG	DEG_APCC_DBOX_1	0.5654
p.L41V	Detroit562	upper_aerodigestive_tract	COSMIC	LRQGLARLG	DEG_APCC_DBOX_1	0.5654

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BV35	Calcium-binding mitochondrial carrier protein SCaMC-3	DEG_APCC_DBOX_1	34:42	LRQGLARLG	APC,CDC20,FZR1	0.5654	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons