DegronMD - Q9BV36(MLPH)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R375H	TCGA-AA-A010	COAD	TCGA	LRRKLEELT	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.0556
p.R375C	TCGA-B5-A11E	UCEC	TCGA	LRRKLEELT	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.0556
p.R375C	DO41644	UCEC	ICGC	LRRKLEELT	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.0556
p.R375C	SIDM00711	Squamous Cell Lung Carcinoma	GDSC	LRRKLEELT	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.0556
p.R375C	NCI-H2066	lung	COSMIC	LRRKLEELT	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.0556
p.E390D	TCGA-B5-A3FC	UCEC	TCGA	LRRKLEELT	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.5647
p.E390D	DO41871	UCEC	ICGC	LRRKLEELT	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.5647
p.E391K	TCGA-EA-A97N	CESC	TCGA	LRRKLEELT	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.591
p.E391K	DO49935	CESC	ICGC	LRRKLEELT	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.591
p.E391K	SIDM00656	Burkitt's Lymphoma	GDSC	LRRKLEELT	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.591
p.E391K	SIDM01318	Hepatocellular Carcinoma	GDSC	LRRKLEELT	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.591
p.E391K	SIDM00641	Burkitt's Lymphoma	GDSC	LRRKLEELT	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.591
p.E391K	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	LRRKLEELT	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.591
p.E391K	NAMALWA	haematopoietic and lymphoid tissue	COSMIC	LRRKLEELT	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.591
p.S397G	TCGA-EE-A2GN	SKCM	TCGA	LRRKLEELT	DEG_APCC_DBOX_1	385:393	Mutation blocking phosphorylation signal	0.6667
p.S397G	DO37896	SKCM	ICGC	LRRKLEELT	DEG_APCC_DBOX_1	385:393	Mutation blocking phosphorylation signal	0.6667
p.E377K	TCGA-ER-A198	SKCM	TCGA	LRRKLEELT	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.1111
p.E377K	DO47563	SKCM	ICGC	LRRKLEELT	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.1111
p.E383K	TCGA-VS-A958	CESC	TCGA	LRRKLEELT	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.2778
p.E383K	DO51639	CESC	ICGC	LRRKLEELT	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.2778
p.E383K	M14	skin	COSMIC	LRRKLEELT	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.2778
p.N388T	DO13024	GBM	ICGC	LRRKLEELT	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.7055
p.D379N	DO229224	THCA	ICGC	LRRKLEELT	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.1667
p.A378V	DO229232	THCA	ICGC	LRRKLEELT	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.1389
p.T379M	DO41289	UCEC	ICGC	LRRKLEELT	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.1667
p.E391V	SIDM00656	Burkitt's Lymphoma	GDSC	LRRKLEELT	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.6582
p.E391V	SIDM01318	Hepatocellular Carcinoma	GDSC	LRRKLEELT	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.6582
p.E391V	SIDM00641	Burkitt's Lymphoma	GDSC	LRRKLEELT	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.6582
p.E391V	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	LRRKLEELT	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.6582
p.E391V	NAMALWA	haematopoietic and lymphoid tissue	COSMIC	LRRKLEELT	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.6582
p.N395S	SIDM00878	Breast Carcinoma	GDSC	LRRKLEELT	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.2778
p.N395S	HCC1569	breast	COSMIC	LRRKLEELT	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.2778

Kaplan plot for MLPH in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MLPH

UniProt ID: Q9BV36

Entrez ID: 79083

Protein name: Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MLPH in