DegronMD

Uniprot ID: Q9BV36

Source protein: Melanophilin

Source gene: MLPH

Class: DEG_APCC_DBOX_1

Location: 385:393

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9665

ASA_SCORE: 101.6333

COIL: 0.1633

CONS_SCORE: 0.6801

DSS_SCORE: 0.5702

HELIX: 0.8364

FCONS_SCORE: 1.2293

RIG_SCORE: 0.7537

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R375H	TCGA-AA-A010	COAD	TCGA	LRRKLEELT	DEG_APCC_DBOX_1	0.0556
p.R375C	TCGA-B5-A11E	UCEC	TCGA	LRRKLEELT	DEG_APCC_DBOX_1	0.0556
p.R375C	DO41644	UCEC	ICGC	LRRKLEELT	DEG_APCC_DBOX_1	0.0556
p.R375C	SIDM00711	Squamous Cell Lung Carcinoma	GDSC	LRRKLEELT	DEG_APCC_DBOX_1	0.0556
p.R375C	NCI-H2066	lung	COSMIC	LRRKLEELT	DEG_APCC_DBOX_1	0.0556
p.E390D	TCGA-B5-A3FC	UCEC	TCGA	LRRKLEELT	DEG_APCC_DBOX_1	0.5647
p.E390D	DO41871	UCEC	ICGC	LRRKLEELT	DEG_APCC_DBOX_1	0.5647
p.E391K	TCGA-EA-A97N	CESC	TCGA	LRRKLEELT	DEG_APCC_DBOX_1	0.591
p.E391K	DO49935	CESC	ICGC	LRRKLEELT	DEG_APCC_DBOX_1	0.591
p.E391K	SIDM00656	Burkitt's Lymphoma	GDSC	LRRKLEELT	DEG_APCC_DBOX_1	0.591
p.E391K	SIDM01318	Hepatocellular Carcinoma	GDSC	LRRKLEELT	DEG_APCC_DBOX_1	0.591
p.E391K	SIDM00641	Burkitt's Lymphoma	GDSC	LRRKLEELT	DEG_APCC_DBOX_1	0.591
p.E391K	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	LRRKLEELT	DEG_APCC_DBOX_1	0.591
p.E391K	NAMALWA	haematopoietic_and_lymphoid_tissue	COSMIC	LRRKLEELT	DEG_APCC_DBOX_1	0.591
p.S397G	TCGA-EE-A2GN	SKCM	TCGA	LRRKLEELT	DEG_APCC_DBOX_1	0.6667
p.S397G	DO37896	SKCM	ICGC	LRRKLEELT	DEG_APCC_DBOX_1	0.6667
p.E377K	TCGA-ER-A198	SKCM	TCGA	LRRKLEELT	DEG_APCC_DBOX_1	0.1111
p.E377K	DO47563	SKCM	ICGC	LRRKLEELT	DEG_APCC_DBOX_1	0.1111
p.E383K	TCGA-VS-A958	CESC	TCGA	LRRKLEELT	DEG_APCC_DBOX_1	0.2778
p.E383K	DO51639	CESC	ICGC	LRRKLEELT	DEG_APCC_DBOX_1	0.2778
p.E383K	M14	skin	COSMIC	LRRKLEELT	DEG_APCC_DBOX_1	0.2778
p.N388T	DO13024	GBM	ICGC	LRRKLEELT	DEG_APCC_DBOX_1	0.7055
p.D379N	DO229224	THCA	ICGC	LRRKLEELT	DEG_APCC_DBOX_1	0.1667
p.A378V	DO229232	THCA	ICGC	LRRKLEELT	DEG_APCC_DBOX_1	0.1389
p.T379M	DO41289	UCEC	ICGC	LRRKLEELT	DEG_APCC_DBOX_1	0.1667
p.E391V	SIDM00656	Burkitt's Lymphoma	GDSC	LRRKLEELT	DEG_APCC_DBOX_1	0.6582
p.E391V	SIDM01318	Hepatocellular Carcinoma	GDSC	LRRKLEELT	DEG_APCC_DBOX_1	0.6582
p.E391V	SIDM00641	Burkitt's Lymphoma	GDSC	LRRKLEELT	DEG_APCC_DBOX_1	0.6582
p.E391V	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	LRRKLEELT	DEG_APCC_DBOX_1	0.6582
p.E391V	NAMALWA	haematopoietic_and_lymphoid_tissue	COSMIC	LRRKLEELT	DEG_APCC_DBOX_1	0.6582
p.N395S	SIDM00878	Breast Carcinoma	GDSC	LRRKLEELT	DEG_APCC_DBOX_1	0.2778
p.N395S	HCC1569	breast	COSMIC	LRRKLEELT	DEG_APCC_DBOX_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRRKLEELT

Degron related mutations and impact score

Drug responses associated with MLPH mutations

All proteins holding degron of LRRKLEELT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BV36	Melanophilin	DEG_APCC_DBOX_1	385:393	LRRKLEELT	APC,CDC20,FZR1	0.9665	More...