DegronMD - Q9BV68(RNF126)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A56S	TCGA-AU-6004	COAD	TCGA	SRPPLEHVD	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.1944
p.A56S	TCGA-IB-7651	PAAD	TCGA	SRPPLEHVD	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.1944
p.A56S	DO7780	COAD	ICGC	SRPPLEHVD	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.1944
p.A56S	DO46657	PAAD	ICGC	SRPPLEHVD	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.1944
p.P76Q	TCGA-D3-A1Q3	SKCM	TCGA	SRPPLEHVD	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.1389
p.P76Q	DO47509	SKCM	ICGC	SRPPLEHVD	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.1389
p.Q77H	TCGA-D3-A2JC	SKCM	TCGA	SRPPLEHVD	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.1111
p.Q77H	DO47578	SKCM	ICGC	SRPPLEHVD	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.1111
p.L72M	TCGA-D3-A3CF	SKCM	TCGA	SRPPLEHVD	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.25
p.L72M	DO37675	SKCM	ICGC	SRPPLEHVD	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.25
p.V68M	DO48453	BLCA	ICGC	SRPPLEHVD	DEG_APCC_DBOX_1	61:69	Mutation altering degron motif	0.6097
p.V68M	DO229003	COCA	ICGC	SRPPLEHVD	DEG_APCC_DBOX_1	61:69	Mutation altering degron motif	0.6097
p.V68M	DO229005	COCA	ICGC	SRPPLEHVD	DEG_APCC_DBOX_1	61:69	Mutation altering degron motif	0.6097
p.V68M	DO229480	LAML	ICGC	SRPPLEHVD	DEG_APCC_DBOX_1	61:69	Mutation altering degron motif	0.6097
p.V68M	DO51035	LAML	ICGC	SRPPLEHVD	DEG_APCC_DBOX_1	61:69	Mutation altering degron motif	0.6097
p.V68M	DO228941	LICA	ICGC	SRPPLEHVD	DEG_APCC_DBOX_1	61:69	Mutation altering degron motif	0.6097
p.P76L	DO233944	GACA	ICGC	SRPPLEHVD	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.1389
p.P76L	SIDM00951	T-Lymphoblastic Leukemia	GDSC	SRPPLEHVD	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.1389
p.P76L	CTV-1	haematopoietic and lymphoid tissue	COSMIC	SRPPLEHVD	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.1389
p.F73L	DO229038	LICA	ICGC	SRPPLEHVD	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.2222
p.A52D	DO229006	LICA	ICGC	SRPPLEHVD	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.0833
p.Q60H	DO27869	ORCA	ICGC	SRPPLEHVD	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.3056
p.S54C	DO27919	ORCA	ICGC	SRPPLEHVD	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.1389
p.P63L	ACH-001415	Bladder Cancer	CCLE	SRPPLEHVD	DEG_APCC_DBOX_1	61:69	Mutation altering degron motif	0.6471

Kaplan plot for RNF126 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RNF126

UniProt ID: Q9BV68

Entrez ID: 55658

Protein name: E3 ubiquitin-protein ligase RNF126 (EC 2.3.2.27) (RING finger protein 126)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RNF126 in