DegronMD

Uniprot ID: Q9BV68

Source protein: E3 ubiquitin-protein ligase RNF126

Source gene: RNF126

Class: DEG_APCC_DBOX_1

Location: 61:69

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7177

ASA_SCORE: 66.1667

COIL: 0.7592

CONS_SCORE: 0.3052

DSS_SCORE: 0.666

HELIX: 0.2048

FCONS_SCORE: 0.9842

RIG_SCORE: 0.6707

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P63L	ACH-001415	Bladder Cancer	CCLE	SRPPLEHVD	DEG_APCC_DBOX_1	0.6471
p.V68M	DO48453	BLCA	ICGC	SRPPLEHVD	DEG_APCC_DBOX_1	0.6097
p.V68M	DO229003	COCA	ICGC	SRPPLEHVD	DEG_APCC_DBOX_1	0.6097
p.V68M	DO229005	COCA	ICGC	SRPPLEHVD	DEG_APCC_DBOX_1	0.6097
p.V68M	DO229480	LAML	ICGC	SRPPLEHVD	DEG_APCC_DBOX_1	0.6097
p.V68M	DO51035	LAML	ICGC	SRPPLEHVD	DEG_APCC_DBOX_1	0.6097
p.V68M	DO228941	LICA	ICGC	SRPPLEHVD	DEG_APCC_DBOX_1	0.6097
p.Q60H	DO27869	ORCA	ICGC	SRPPLEHVD	DEG_APCC_DBOX_1	0.3056
p.L72M	TCGA-D3-A3CF	SKCM	TCGA	SRPPLEHVD	DEG_APCC_DBOX_1	0.25
p.L72M	DO37675	SKCM	ICGC	SRPPLEHVD	DEG_APCC_DBOX_1	0.25
p.F73L	DO229038	LICA	ICGC	SRPPLEHVD	DEG_APCC_DBOX_1	0.2222
p.A56S	TCGA-AU-6004	COAD	TCGA	SRPPLEHVD	DEG_APCC_DBOX_1	0.1944
p.A56S	TCGA-IB-7651	PAAD	TCGA	SRPPLEHVD	DEG_APCC_DBOX_1	0.1944
p.A56S	DO7780	COAD	ICGC	SRPPLEHVD	DEG_APCC_DBOX_1	0.1944
p.A56S	DO46657	PAAD	ICGC	SRPPLEHVD	DEG_APCC_DBOX_1	0.1944
p.P76Q	TCGA-D3-A1Q3	SKCM	TCGA	SRPPLEHVD	DEG_APCC_DBOX_1	0.1389
p.P76Q	DO47509	SKCM	ICGC	SRPPLEHVD	DEG_APCC_DBOX_1	0.1389
p.P76L	DO233944	GACA	ICGC	SRPPLEHVD	DEG_APCC_DBOX_1	0.1389
p.P76L	SIDM00951	T-Lymphoblastic Leukemia	GDSC	SRPPLEHVD	DEG_APCC_DBOX_1	0.1389
p.P76L	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	SRPPLEHVD	DEG_APCC_DBOX_1	0.1389
p.S54C	DO27919	ORCA	ICGC	SRPPLEHVD	DEG_APCC_DBOX_1	0.1389
p.Q77H	TCGA-D3-A2JC	SKCM	TCGA	SRPPLEHVD	DEG_APCC_DBOX_1	0.1111
p.Q77H	DO47578	SKCM	ICGC	SRPPLEHVD	DEG_APCC_DBOX_1	0.1111
p.A52D	DO229006	LICA	ICGC	SRPPLEHVD	DEG_APCC_DBOX_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BV68	E3 ubiquitin-protein ligase RNF126	DEG_APCC_DBOX_1	61:69	SRPPLEHVD	APC,CDC20,FZR1	0.7177	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons