DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
SRPPLEHVD
Uniprot ID:
Q9BV68
Source protein:
E3 ubiquitin-protein ligase RNF126
Source gene:
RNF126
Class:
DEG_APCC_DBOX_1
Location:
61:69
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.7177
ASA_SCORE:
66.1667
COIL:
0.7592
CONS_SCORE:
0.3052
DSS_SCORE:
0.666
HELIX:
0.2048
FCONS_SCORE:
0.9842
RIG_SCORE:
0.6707
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A56S
TCGA-AU-6004
COAD
TCGA
SRPPLEHVD
DEG_APCC_DBOX_1
0.1944
p.A56S
TCGA-IB-7651
PAAD
TCGA
SRPPLEHVD
DEG_APCC_DBOX_1
0.1944
p.A56S
DO7780
COAD
ICGC
SRPPLEHVD
DEG_APCC_DBOX_1
0.1944
p.A56S
DO46657
PAAD
ICGC
SRPPLEHVD
DEG_APCC_DBOX_1
0.1944
p.P76Q
TCGA-D3-A1Q3
SKCM
TCGA
SRPPLEHVD
DEG_APCC_DBOX_1
0.1389
p.P76Q
DO47509
SKCM
ICGC
SRPPLEHVD
DEG_APCC_DBOX_1
0.1389
p.Q77H
TCGA-D3-A2JC
SKCM
TCGA
SRPPLEHVD
DEG_APCC_DBOX_1
0.1111
p.Q77H
DO47578
SKCM
ICGC
SRPPLEHVD
DEG_APCC_DBOX_1
0.1111
p.L72M
TCGA-D3-A3CF
SKCM
TCGA
SRPPLEHVD
DEG_APCC_DBOX_1
0.25
p.L72M
DO37675
SKCM
ICGC
SRPPLEHVD
DEG_APCC_DBOX_1
0.25
p.V68M
DO48453
BLCA
ICGC
SRPPLEHVD
DEG_APCC_DBOX_1
0.6097
p.V68M
DO229003
COCA
ICGC
SRPPLEHVD
DEG_APCC_DBOX_1
0.6097
p.V68M
DO229005
COCA
ICGC
SRPPLEHVD
DEG_APCC_DBOX_1
0.6097
p.V68M
DO229480
LAML
ICGC
SRPPLEHVD
DEG_APCC_DBOX_1
0.6097
p.V68M
DO51035
LAML
ICGC
SRPPLEHVD
DEG_APCC_DBOX_1
0.6097
p.V68M
DO228941
LICA
ICGC
SRPPLEHVD
DEG_APCC_DBOX_1
0.6097
p.P76L
DO233944
GACA
ICGC
SRPPLEHVD
DEG_APCC_DBOX_1
0.1389
p.P76L
SIDM00951
T-Lymphoblastic Leukemia
GDSC
SRPPLEHVD
DEG_APCC_DBOX_1
0.1389
p.P76L
CTV-1
haematopoietic_and_lymphoid_tissue
COSMIC
SRPPLEHVD
DEG_APCC_DBOX_1
0.1389
p.F73L
DO229038
LICA
ICGC
SRPPLEHVD
DEG_APCC_DBOX_1
0.2222
p.A52D
DO229006
LICA
ICGC
SRPPLEHVD
DEG_APCC_DBOX_1
0.0833
p.Q60H
DO27869
ORCA
ICGC
SRPPLEHVD
DEG_APCC_DBOX_1
0.3056
p.S54C
DO27919
ORCA
ICGC
SRPPLEHVD
DEG_APCC_DBOX_1
0.1389
p.P63L
ACH-001415
Bladder Cancer
CCLE
SRPPLEHVD
DEG_APCC_DBOX_1
0.6471
Drug responses associated with RNF126 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of SRPPLEHVD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9BV68
E3 ubiquitin-protein ligase RNF126
DEG_APCC_DBOX_1
61:69
SRPPLEHVD
APC,CDC20,FZR1
0.7177
More...