DegronMD - Q9BV79(MECR)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F250V	TCGA-19-5956	GBM	TCGA	PRLALNCVG	DEG_APCC_DBOX_1	257:265	Mutation rewiring degron network	0.1389
p.F250V	DO13863	GBM	ICGC	PRLALNCVG	DEG_APCC_DBOX_1	257:265	Mutation rewiring degron network	0.1389
p.K252R	TCGA-AP-A056	UCEC	TCGA	PRLALNCVG	DEG_APCC_DBOX_1	257:265	Mutation substituting flanking lysine	0.3056
p.K252R	DO43971	UCEC	ICGC	PRLALNCVG	DEG_APCC_DBOX_1	257:265	Mutation substituting flanking lysine	0.3056
p.F250L	TCGA-AP-A1DV	UCEC	TCGA	PRLALNCVG	DEG_APCC_DBOX_1	257:265	Mutation rewiring degron network	0.1389
p.F250L	DO43186	UCEC	ICGC	PRLALNCVG	DEG_APCC_DBOX_1	257:265	Mutation rewiring degron network	0.1389
p.F250L	SIDM00534	Colorectal Carcinoma	GDSC	PRLALNCVG	DEG_APCC_DBOX_1	257:265	Mutation rewiring degron network	0.1389
p.F250L	ACH-000986	Colon/Colorectal Cancer	CCLE	PRLALNCVG	DEG_APCC_DBOX_1	257:265	Mutation rewiring degron network	0.1389
p.F250L	HT-115	large intestine	COSMIC	PRLALNCVG	DEG_APCC_DBOX_1	257:265	Mutation rewiring degron network	0.1389
p.R274W	TCGA-DF-A2KU	UCEC	TCGA	PRLALNCVG	DEG_APCC_DBOX_1	257:265	Mutation rewiring degron network	0.0833
p.R274W	TCGA-E6-A2P8	UCEC	TCGA	PRLALNCVG	DEG_APCC_DBOX_1	257:265	Mutation rewiring degron network	0.0833
p.R274W	DO40924	UCEC	ICGC	PRLALNCVG	DEG_APCC_DBOX_1	257:265	Mutation rewiring degron network	0.0833
p.R274W	DO223286	UCEC	ICGC	PRLALNCVG	DEG_APCC_DBOX_1	257:265	Mutation rewiring degron network	0.0833
p.T270I	TCGA-EJ-7318	PRAD	TCGA	PRLALNCVG	DEG_APCC_DBOX_1	257:265	Mutation rewiring degron network	0.1944
p.T270I	DO51313	PRAD	ICGC	PRLALNCVG	DEG_APCC_DBOX_1	257:265	Mutation rewiring degron network	0.1944
p.S269Y	DO229027	LICA	ICGC	PRLALNCVG	DEG_APCC_DBOX_1	257:265	Mutation rewiring degron network	0.2222
p.R258L	SIDM00529	Breast Carcinoma	GDSC	PRLALNCVG	DEG_APCC_DBOX_1	257:265	Mutation altering degron motif	0.8428
p.R258L	SIDM00257	Neuroblastoma	GDSC	PRLALNCVG	DEG_APCC_DBOX_1	257:265	Mutation altering degron motif	0.8428
p.R258L	SIDM01318	Hepatocellular Carcinoma	GDSC	PRLALNCVG	DEG_APCC_DBOX_1	257:265	Mutation altering degron motif	0.8428
p.K267R	SIDM00494	Non-Small Cell Lung Carcinoma	GDSC	PRLALNCVG	DEG_APCC_DBOX_1	257:265	Mutation blocking ubiquitination signal	0.7222
p.K267R	ACH-000528	Lung Cancer	CCLE	PRLALNCVG	DEG_APCC_DBOX_1	257:265	Mutation blocking ubiquitination signal	0.7222
p.K267R	ABC-1	lung	COSMIC	PRLALNCVG	DEG_APCC_DBOX_1	257:265	Mutation blocking ubiquitination signal	0.7222
p.I259V	DOV13	ovary	COSMIC	PRLALNCVG	DEG_APCC_DBOX_1	257:265	Mutation altering degron motif	0.7076

Kaplan plot for MECR in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MECR

UniProt ID: Q9BV79

Entrez ID: 51102

Protein name: Enoyl-[acyl-carrier-protein] reductase, mitochondrial (EC 1.3.1.104) (2-enoyl thioester reductase) (Nuclear receptor-binding factor 1) (HsNrbf-1) (NRBF-1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for MECR in