DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PRLALNCVG
Uniprot ID:
Q9BV79
Source protein:
Enoyl-[acyl-carrier-protein] reductase, mitochondrial
Source gene:
MECR
Class:
DEG_APCC_DBOX_1
Location:
257:265
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.751
ASA_SCORE:
13.4556
COIL:
0.4713
CONS_SCORE:
0.5795
DSS_SCORE:
0.4002
HELIX:
0.0114
FCONS_SCORE:
1.4809
RIG_SCORE:
0.7752
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.F250V
TCGA-19-5956
GBM
TCGA
PRLALNCVG
DEG_APCC_DBOX_1
0.1389
p.F250V
DO13863
GBM
ICGC
PRLALNCVG
DEG_APCC_DBOX_1
0.1389
p.K252R
TCGA-AP-A056
UCEC
TCGA
PRLALNCVG
DEG_APCC_DBOX_1
0.3056
p.K252R
DO43971
UCEC
ICGC
PRLALNCVG
DEG_APCC_DBOX_1
0.3056
p.F250L
TCGA-AP-A1DV
UCEC
TCGA
PRLALNCVG
DEG_APCC_DBOX_1
0.1389
p.F250L
DO43186
UCEC
ICGC
PRLALNCVG
DEG_APCC_DBOX_1
0.1389
p.F250L
SIDM00534
Colorectal Carcinoma
GDSC
PRLALNCVG
DEG_APCC_DBOX_1
0.1389
p.F250L
ACH-000986
Colon/Colorectal Cancer
CCLE
PRLALNCVG
DEG_APCC_DBOX_1
0.1389
p.F250L
HT-115
large_intestine
COSMIC
PRLALNCVG
DEG_APCC_DBOX_1
0.1389
p.R274W
TCGA-DF-A2KU
UCEC
TCGA
PRLALNCVG
DEG_APCC_DBOX_1
0.0833
p.R274W
TCGA-E6-A2P8
UCEC
TCGA
PRLALNCVG
DEG_APCC_DBOX_1
0.0833
p.R274W
DO40924
UCEC
ICGC
PRLALNCVG
DEG_APCC_DBOX_1
0.0833
p.R274W
DO223286
UCEC
ICGC
PRLALNCVG
DEG_APCC_DBOX_1
0.0833
p.T270I
TCGA-EJ-7318
PRAD
TCGA
PRLALNCVG
DEG_APCC_DBOX_1
0.1944
p.T270I
DO51313
PRAD
ICGC
PRLALNCVG
DEG_APCC_DBOX_1
0.1944
p.S269Y
DO229027
LICA
ICGC
PRLALNCVG
DEG_APCC_DBOX_1
0.2222
p.R258L
SIDM00529
Breast Carcinoma
GDSC
PRLALNCVG
DEG_APCC_DBOX_1
0.8428
p.R258L
SIDM00257
Neuroblastoma
GDSC
PRLALNCVG
DEG_APCC_DBOX_1
0.8428
p.R258L
SIDM01318
Hepatocellular Carcinoma
GDSC
PRLALNCVG
DEG_APCC_DBOX_1
0.8428
p.K267R
SIDM00494
Non-Small Cell Lung Carcinoma
GDSC
PRLALNCVG
DEG_APCC_DBOX_1
0.7222
p.K267R
ACH-000528
Lung Cancer
CCLE
PRLALNCVG
DEG_APCC_DBOX_1
0.7222
p.K267R
ABC-1
lung
COSMIC
PRLALNCVG
DEG_APCC_DBOX_1
0.7222
p.I259V
DOV13
ovary
COSMIC
PRLALNCVG
DEG_APCC_DBOX_1
0.7076
Drug responses associated with MECR mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PRLALNCVG
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9BV79
Enoyl-[acyl-carrier-protein] reductase, mitochondrial
DEG_APCC_DBOX_1
257:265
PRLALNCVG
APC,CDC20,FZR1
0.751
More...