NTMT1
UniProt ID: Q9BV86
Entrez ID: 28989
Protein name: N-terminal Xaa-Pro-Lys N-methyltransferase 1 (EC 2.1.1.244) (Alpha N-terminal protein methyltransferase 1A) (Methyltransferase-like protein 11A) (N-terminal RCC1 methyltransferase) (X-Pro-Lys N-terminal protein methyltransferase 1A) (NTM1A) [Cleaved into: N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed]
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser...
FUNCTION: Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by NTMT2-mediated monomethylation (PubMed:24090352). Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1. {ECO:0000269|PubMed:20481588, ECO:0000269|PubMed:20668449, ECO:0000269|PubMed:24090352, ECO:0000269|PubMed:26543159}.
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GO - Biological processes (BP):
chromosome segregation [GO:0007059]; histone methylation [GO:0016571]; N-terminal peptidyl-alanine methylation [GO:0018011]; N-terminal peptidyl-alanine trimethylation [GO:0018012]; N-terminal peptidyl-glycine methylation [GO:0018013]; N-terminal peptidyl-proline dimethylation [GO:0018016]; N-termin...
chromosome segregation [GO:0007059]; histone methylation [GO:0016571]; N-terminal peptidyl-alanine methylation [GO:0018011]; N-terminal peptidyl-alanine trimethylation [GO:0018012]; N-terminal peptidyl-glycine methylation [GO:0018013]; N-terminal peptidyl-proline dimethylation [GO:0018016]; N-terminal peptidyl-proline methylation [GO:0035568]; N-terminal peptidyl-serine dimethylation [GO:0035572]; N-terminal peptidyl-serine methylation [GO:0035570]; N-terminal peptidyl-serine trimethylation [GO:0035573]; N-terminal protein amino acid methylation [GO:0006480]; spindle organization [GO:0007051]
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GO - Molecular function (MF):
histone methyltransferase activity [GO:0042054]; methyltransferase activity [GO:0008168]; N-terminal protein N-methyltransferase activity [GO:0071885]; protein methyltransferase activity [GO:0008276]...
histone methyltransferase activity [GO:0042054]; methyltransferase activity [GO:0008168]; N-terminal protein N-methyltransferase activity [GO:0071885]; protein methyltransferase activity [GO:0008276]
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GO - Cellular component (CC):
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]...
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]
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NTMT1
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Kaplan plot for NTMT1 in
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*NOTE: the Kaplan plots were collected from OncoLnc