DegronMD

Uniprot ID: Q9BV86

Source protein: N-terminal Xaa-Pro-Lys N-methyltransferase 1

Source gene: NTMT1

Class: DEG_APCC_TPR_1

Location: 221:223

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9743

ASA_SCORE: 79.7333

COIL: 0.7363

CONS_SCORE: 0.7896

DSS_SCORE: 0.5214

HELIX: 0.125

FCONS_SCORE: 0.9824

RIG_SCORE: 0.8238

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D212N	TCGA-A5-A2K5	UCEC	TCGA	ALR	DEG_APCC_TPR_1	0.0833
p.D212N	TCGA-D7-A4YV	STAD	TCGA	ALR	DEG_APCC_TPR_1	0.0833
p.D212N	TCGA-IB-7651	PAAD	TCGA	ALR	DEG_APCC_TPR_1	0.0833
p.H216Q	TCGA-AA-3663	COAD	TCGA	ALR	DEG_APCC_TPR_1	0.1944
p.E213Q	TCGA-CX-7085	HNSC	TCGA	ALR	DEG_APCC_TPR_1	0.1111
p.P211S	ACH-000980	Lung Cancer	CCLE	ALR	DEG_APCC_TPR_1	0.0556
p.P211S	NCI-H1155	lung	COSMIC	ALR	DEG_APCC_TPR_1	0.0556
p.E213D	ACH-000996	Endometrial/Uterine Cancer	CCLE	ALR	DEG_APCC_TPR_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BV86	N-terminal Xaa-Pro-Lys N-methyltransferase 1	DEG_APCC_TPR_1	221:223	ALR	APC,CDC20,FZR1	0.9743	More...
Q8IWA6	Coiled-coil domain-containing protein 60	DEG_APCC_TPR_1	548:550	ALR	APC,CDC20,FZR1	0.9149	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons