DegronMD

Uniprot ID: Q8IWA6

Source protein: Coiled-coil domain-containing protein 60

Source gene: CCDC60

Class: DEG_APCC_TPR_1

Location: 548:550

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9149

ASA_SCORE: 121.3333

COIL: 0.854

CONS_SCORE: 0.5236

DSS_SCORE: 0.6559

HELIX: 0.151

FCONS_SCORE: 1.0906

RIG_SCORE: 0.7706

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y546N	TCGA-DD-AACL	LIHC	TCGA	ALR	DEG_APCC_TPR_1	0.2778
p.Y546N	DO52208	LIHC	ICGC	ALR	DEG_APCC_TPR_1	0.2778
p.R538Q	DO233084	GACA	ICGC	ALR	DEG_APCC_TPR_1	0.0556
p.S547N	SIDM01203	Other Solid Cancers	GDSC	ALR	DEG_APCC_TPR_1	0.3056
p.S547N	SIDM00339	Non-Small Cell Lung Carcinoma	GDSC	ALR	DEG_APCC_TPR_1	0.3056
p.S547R	SIDM01203	Other Solid Cancers	GDSC	ALR	DEG_APCC_TPR_1	0.3056
p.S547R	SIDM00339	Non-Small Cell Lung Carcinoma	GDSC	ALR	DEG_APCC_TPR_1	0.3056
p.I541M	SIDM00789	Colorectal Carcinoma	GDSC	ALR	DEG_APCC_TPR_1	0.1389
p.I541M	ACH-000997	Colon/Colorectal Cancer	CCLE	ALR	DEG_APCC_TPR_1	0.1389
p.I541M	HCT-15	large_intestine	COSMIC	ALR	DEG_APCC_TPR_1	0.1389
p.G544A	ACH-001607	Gallbladder Cancer	CCLE	ALR	DEG_APCC_TPR_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BV86	N-terminal Xaa-Pro-Lys N-methyltransferase 1	DEG_APCC_TPR_1	221:223	ALR	APC,CDC20,FZR1	0.9743	More...
Q8IWA6	Coiled-coil domain-containing protein 60	DEG_APCC_TPR_1	548:550	ALR	APC,CDC20,FZR1	0.9149	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons