DegronMD - Q8IWA6(CCDC60)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G125E	TCGA-22-5474	LUSC	TCGA	PFTPIHS	DEG_SCF_FBW7_1	132:138	Mutation rewiring degron network	0.1389
p.G125E	TCGA-D3-A8GI	SKCM	TCGA	PFTPIHS	DEG_SCF_FBW7_1	132:138	Mutation rewiring degron network	0.1389
p.G125E	DO26578	LUSC	ICGC	PFTPIHS	DEG_SCF_FBW7_1	132:138	Mutation rewiring degron network	0.1389
p.G125E	DO50284	SKCM	ICGC	PFTPIHS	DEG_SCF_FBW7_1	132:138	Mutation rewiring degron network	0.1389
p.R131H	TCGA-24-1104	OV	TCGA	PFTPIHS	DEG_SCF_FBW7_1	132:138	Mutation rewiring degron network	0.3056
p.R131H	TCGA-IB-7651	PAAD	TCGA	PFTPIHS	DEG_SCF_FBW7_1	132:138	Mutation rewiring degron network	0.3056
p.R131H	DO8730	COAD	ICGC	PFTPIHS	DEG_SCF_FBW7_1	132:138	Mutation rewiring degron network	0.3056
p.R131H	DO31909	OV	ICGC	PFTPIHS	DEG_SCF_FBW7_1	132:138	Mutation rewiring degron network	0.3056
p.R131H	DO46657	PAAD	ICGC	PFTPIHS	DEG_SCF_FBW7_1	132:138	Mutation rewiring degron network	0.3056
p.R131H	SIDM00777	Colorectal Carcinoma	GDSC	PFTPIHS	DEG_SCF_FBW7_1	132:138	Mutation rewiring degron network	0.3056
p.R131H	ACH-000360	Colon/Colorectal Cancer	CCLE	PFTPIHS	DEG_SCF_FBW7_1	132:138	Mutation rewiring degron network	0.3056
p.R131H	NCI-H508	large intestine	COSMIC	PFTPIHS	DEG_SCF_FBW7_1	132:138	Mutation rewiring degron network	0.3056
p.L124M	TCGA-AJ-A3BH	UCEC	TCGA	PFTPIHS	DEG_SCF_FBW7_1	132:138	Mutation rewiring degron network	0.1111
p.L124M	DO41638	UCEC	ICGC	PFTPIHS	DEG_SCF_FBW7_1	132:138	Mutation rewiring degron network	0.1111
p.T129I	TCGA-BR-A4QL	STAD	TCGA	PFTPIHS	DEG_SCF_FBW7_1	132:138	Mutation rewiring degron network	0.25
p.T129I	DO38723	STAD	ICGC	PFTPIHS	DEG_SCF_FBW7_1	132:138	Mutation rewiring degron network	0.25
p.Y546N	TCGA-DD-AACL	LIHC	TCGA	ALR	DEG_APCC_TPR_1	548:550	Mutation rewiring degron network	0.2778
p.Y546N	DO52208	LIHC	ICGC	ALR	DEG_APCC_TPR_1	548:550	Mutation rewiring degron network	0.2778
p.H137Y	TCGA-EB-A41B	SKCM	TCGA	PFTPIHS	DEG_SCF_FBW7_1	132:138	Mutation altering degron motif	0.6118
p.H137Y	DO37611	SKCM	ICGC	PFTPIHS	DEG_SCF_FBW7_1	132:138	Mutation altering degron motif	0.6118
p.P143H	TCGA-FS-A1ZR	SKCM	TCGA	PFTPIHS	DEG_SCF_FBW7_1	132:138	Mutation rewiring degron network	0.1944
p.P143H	DO37651	SKCM	ICGC	PFTPIHS	DEG_SCF_FBW7_1	132:138	Mutation rewiring degron network	0.1944
p.G125R	TCGA-GF-A4EO	SKCM	TCGA	PFTPIHS	DEG_SCF_FBW7_1	132:138	Mutation rewiring degron network	0.1389
p.G125R	DO47559	SKCM	ICGC	PFTPIHS	DEG_SCF_FBW7_1	132:138	Mutation rewiring degron network	0.1389
p.A148D	DO222798	COCA	ICGC	PFTPIHS	DEG_SCF_FBW7_1	132:138	Mutation rewiring degron network	0.0556
p.T123A	DO229010	COCA	ICGC	PFTPIHS	DEG_SCF_FBW7_1	132:138	Mutation rewiring degron network	0.0833
p.T123A	DO229013	COCA	ICGC	PFTPIHS	DEG_SCF_FBW7_1	132:138	Mutation rewiring degron network	0.0833
p.T123A	DO229016	COCA	ICGC	PFTPIHS	DEG_SCF_FBW7_1	132:138	Mutation rewiring degron network	0.0833
p.T123A	DO229003	COCA	ICGC	PFTPIHS	DEG_SCF_FBW7_1	132:138	Mutation rewiring degron network	0.0833
p.T123A	DO229005	COCA	ICGC	PFTPIHS	DEG_SCF_FBW7_1	132:138	Mutation rewiring degron network	0.0833
p.T123A	DO229505	LAML	ICGC	PFTPIHS	DEG_SCF_FBW7_1	132:138	Mutation rewiring degron network	0.0833
p.R538Q	DO233084	GACA	ICGC	ALR	DEG_APCC_TPR_1	548:550	Mutation rewiring degron network	0.0556
p.C139F	DO229036	LICA	ICGC	PFTPIHS	DEG_SCF_FBW7_1	132:138	Mutation rewiring degron network	0.3056
p.A148S	DO229036	LICA	ICGC	PFTPIHS	DEG_SCF_FBW7_1	132:138	Mutation rewiring degron network	0.0556
p.S144L	DO36556	READ	ICGC	PFTPIHS	DEG_SCF_FBW7_1	132:138	Mutation rewiring degron network	0.1667
p.P128S	DO229453	SKCA	ICGC	PFTPIHS	DEG_SCF_FBW7_1	132:138	Mutation rewiring degron network	0.2222
p.S547N	SIDM01203	Other Solid Cancers	GDSC	ALR	DEG_APCC_TPR_1	548:550	Mutation rewiring degron network	0.3056
p.S547N	SIDM00339	Non-Small Cell Lung Carcinoma	GDSC	ALR	DEG_APCC_TPR_1	548:550	Mutation rewiring degron network	0.3056
p.S547R	SIDM01203	Other Solid Cancers	GDSC	ALR	DEG_APCC_TPR_1	548:550	Mutation rewiring degron network	0.3056
p.S547R	SIDM00339	Non-Small Cell Lung Carcinoma	GDSC	ALR	DEG_APCC_TPR_1	548:550	Mutation rewiring degron network	0.3056
p.I541M	SIDM00789	Colorectal Carcinoma	GDSC	ALR	DEG_APCC_TPR_1	548:550	Mutation rewiring degron network	0.1389
p.I541M	ACH-000997	Colon/Colorectal Cancer	CCLE	ALR	DEG_APCC_TPR_1	548:550	Mutation rewiring degron network	0.1389
p.I541M	HCT-15	large intestine	COSMIC	ALR	DEG_APCC_TPR_1	548:550	Mutation rewiring degron network	0.1389
p.T129K	SIDM00632	Non-Cancerous	GDSC	PFTPIHS	DEG_SCF_FBW7_1	132:138	Mutation rewiring degron network	0.25
p.T129K	ACH-002247	Non-Cancerous	CCLE	PFTPIHS	DEG_SCF_FBW7_1	132:138	Mutation rewiring degron network	0.25
p.T129K	IM-9	haematopoietic and lymphoid tissue	COSMIC	PFTPIHS	DEG_SCF_FBW7_1	132:138	Mutation rewiring degron network	0.25
p.G544A	ACH-001607	Gallbladder Cancer	CCLE	ALR	DEG_APCC_TPR_1	548:550	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCDC60

UniProt ID: Q8IWA6

Entrez ID: 160777

Protein name: Coiled-coil domain-containing protein 60

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCDC60 in