DegronMD

Uniprot ID: Q8IWA6

Source protein: Coiled-coil domain-containing protein 60

Source gene: CCDC60

Class: DEG_SCF_FBW7_1

Location: 132:138

E3 ligase: FBXW7

DEGRON score: 0.9307

ASA_SCORE: 52.5

COIL: 0.713

CONS_SCORE: 0.6883

DSS_SCORE: 0.1775

HELIX: 0.1023

FCONS_SCORE: 1.5434

RIG_SCORE: 0.7952

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G125E	TCGA-22-5474	LUSC	TCGA	PFTPIHS	DEG_SCF_FBW7_1	0.1389
p.G125E	TCGA-D3-A8GI	SKCM	TCGA	PFTPIHS	DEG_SCF_FBW7_1	0.1389
p.G125E	DO26578	LUSC	ICGC	PFTPIHS	DEG_SCF_FBW7_1	0.1389
p.G125E	DO50284	SKCM	ICGC	PFTPIHS	DEG_SCF_FBW7_1	0.1389
p.R131H	TCGA-24-1104	OV	TCGA	PFTPIHS	DEG_SCF_FBW7_1	0.3056
p.R131H	TCGA-IB-7651	PAAD	TCGA	PFTPIHS	DEG_SCF_FBW7_1	0.3056
p.R131H	DO8730	COAD	ICGC	PFTPIHS	DEG_SCF_FBW7_1	0.3056
p.R131H	DO31909	OV	ICGC	PFTPIHS	DEG_SCF_FBW7_1	0.3056
p.R131H	DO46657	PAAD	ICGC	PFTPIHS	DEG_SCF_FBW7_1	0.3056
p.R131H	SIDM00777	Colorectal Carcinoma	GDSC	PFTPIHS	DEG_SCF_FBW7_1	0.3056
p.R131H	ACH-000360	Colon/Colorectal Cancer	CCLE	PFTPIHS	DEG_SCF_FBW7_1	0.3056
p.R131H	NCI-H508	large_intestine	COSMIC	PFTPIHS	DEG_SCF_FBW7_1	0.3056
p.L124M	TCGA-AJ-A3BH	UCEC	TCGA	PFTPIHS	DEG_SCF_FBW7_1	0.1111
p.L124M	DO41638	UCEC	ICGC	PFTPIHS	DEG_SCF_FBW7_1	0.1111
p.T129I	TCGA-BR-A4QL	STAD	TCGA	PFTPIHS	DEG_SCF_FBW7_1	0.25
p.T129I	DO38723	STAD	ICGC	PFTPIHS	DEG_SCF_FBW7_1	0.25
p.H137Y	TCGA-EB-A41B	SKCM	TCGA	PFTPIHS	DEG_SCF_FBW7_1	0.6118
p.H137Y	DO37611	SKCM	ICGC	PFTPIHS	DEG_SCF_FBW7_1	0.6118
p.P143H	TCGA-FS-A1ZR	SKCM	TCGA	PFTPIHS	DEG_SCF_FBW7_1	0.1944
p.P143H	DO37651	SKCM	ICGC	PFTPIHS	DEG_SCF_FBW7_1	0.1944
p.G125R	TCGA-GF-A4EO	SKCM	TCGA	PFTPIHS	DEG_SCF_FBW7_1	0.1389
p.G125R	DO47559	SKCM	ICGC	PFTPIHS	DEG_SCF_FBW7_1	0.1389
p.A148D	DO222798	COCA	ICGC	PFTPIHS	DEG_SCF_FBW7_1	0.0556
p.T123A	DO229010	COCA	ICGC	PFTPIHS	DEG_SCF_FBW7_1	0.0833
p.T123A	DO229013	COCA	ICGC	PFTPIHS	DEG_SCF_FBW7_1	0.0833
p.T123A	DO229016	COCA	ICGC	PFTPIHS	DEG_SCF_FBW7_1	0.0833
p.T123A	DO229003	COCA	ICGC	PFTPIHS	DEG_SCF_FBW7_1	0.0833
p.T123A	DO229005	COCA	ICGC	PFTPIHS	DEG_SCF_FBW7_1	0.0833
p.T123A	DO229505	LAML	ICGC	PFTPIHS	DEG_SCF_FBW7_1	0.0833
p.C139F	DO229036	LICA	ICGC	PFTPIHS	DEG_SCF_FBW7_1	0.3056
p.A148S	DO229036	LICA	ICGC	PFTPIHS	DEG_SCF_FBW7_1	0.0556
p.S144L	DO36556	READ	ICGC	PFTPIHS	DEG_SCF_FBW7_1	0.1667
p.P128S	DO229453	SKCA	ICGC	PFTPIHS	DEG_SCF_FBW7_1	0.2222
p.T129K	SIDM00632	Non-Cancerous	GDSC	PFTPIHS	DEG_SCF_FBW7_1	0.25
p.T129K	ACH-002247	Non-Cancerous	CCLE	PFTPIHS	DEG_SCF_FBW7_1	0.25
p.T129K	IM-9	haematopoietic_and_lymphoid_tissue	COSMIC	PFTPIHS	DEG_SCF_FBW7_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PFTPIHS

Degron related mutations and impact score

Drug responses associated with CCDC60 mutations

All proteins holding degron of PFTPIHS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWA6	Coiled-coil domain-containing protein 60	DEG_SCF_FBW7_1	132:138	PFTPIHS	FBXW7	0.9307	More...