DegronMD

Uniprot ID: Q8IWA6

Source protein: Coiled-coil domain-containing protein 60

Source gene: CCDC60

Class: DEG_SCF_FBW7_1

Location: 132:138

E3 ligase: FBXW7

DEGRON score: 0.9307

ASA_SCORE: 52.5

COIL: 0.713

CONS_SCORE: 0.6883

DSS_SCORE: 0.1775

HELIX: 0.1023

FCONS_SCORE: 1.5434

RIG_SCORE: 0.7952

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H137Y	TCGA-EB-A41B	SKCM	TCGA	PFTPIHS	DEG_SCF_FBW7_1	0.6118
p.H137Y	DO37611	SKCM	ICGC	PFTPIHS	DEG_SCF_FBW7_1	0.6118
p.R131H	TCGA-24-1104	OV	TCGA	PFTPIHS	DEG_SCF_FBW7_1	0.3056
p.R131H	TCGA-IB-7651	PAAD	TCGA	PFTPIHS	DEG_SCF_FBW7_1	0.3056
p.R131H	DO8730	COAD	ICGC	PFTPIHS	DEG_SCF_FBW7_1	0.3056
p.R131H	DO31909	OV	ICGC	PFTPIHS	DEG_SCF_FBW7_1	0.3056
p.R131H	DO46657	PAAD	ICGC	PFTPIHS	DEG_SCF_FBW7_1	0.3056
p.R131H	SIDM00777	Colorectal Carcinoma	GDSC	PFTPIHS	DEG_SCF_FBW7_1	0.3056
p.R131H	ACH-000360	Colon/Colorectal Cancer	CCLE	PFTPIHS	DEG_SCF_FBW7_1	0.3056
p.R131H	NCI-H508	large_intestine	COSMIC	PFTPIHS	DEG_SCF_FBW7_1	0.3056
p.C139F	DO229036	LICA	ICGC	PFTPIHS	DEG_SCF_FBW7_1	0.3056
p.T129I	TCGA-BR-A4QL	STAD	TCGA	PFTPIHS	DEG_SCF_FBW7_1	0.25
p.T129I	DO38723	STAD	ICGC	PFTPIHS	DEG_SCF_FBW7_1	0.25
p.T129K	SIDM00632	Non-Cancerous	GDSC	PFTPIHS	DEG_SCF_FBW7_1	0.25
p.T129K	ACH-002247	Non-Cancerous	CCLE	PFTPIHS	DEG_SCF_FBW7_1	0.25
p.T129K	IM-9	haematopoietic_and_lymphoid_tissue	COSMIC	PFTPIHS	DEG_SCF_FBW7_1	0.25
p.P128S	DO229453	SKCA	ICGC	PFTPIHS	DEG_SCF_FBW7_1	0.2222
p.P143H	TCGA-FS-A1ZR	SKCM	TCGA	PFTPIHS	DEG_SCF_FBW7_1	0.1944
p.P143H	DO37651	SKCM	ICGC	PFTPIHS	DEG_SCF_FBW7_1	0.1944
p.S144L	DO36556	READ	ICGC	PFTPIHS	DEG_SCF_FBW7_1	0.1667
p.G125E	TCGA-22-5474	LUSC	TCGA	PFTPIHS	DEG_SCF_FBW7_1	0.1389
p.G125E	TCGA-D3-A8GI	SKCM	TCGA	PFTPIHS	DEG_SCF_FBW7_1	0.1389
p.G125E	DO26578	LUSC	ICGC	PFTPIHS	DEG_SCF_FBW7_1	0.1389
p.G125E	DO50284	SKCM	ICGC	PFTPIHS	DEG_SCF_FBW7_1	0.1389
p.G125R	TCGA-GF-A4EO	SKCM	TCGA	PFTPIHS	DEG_SCF_FBW7_1	0.1389

Showing 1 to 25 of 36 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWA6	Coiled-coil domain-containing protein 60	DEG_SCF_FBW7_1	132:138	PFTPIHS	FBXW7	0.9307	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons