DegronMD - Q9BV94(EDEM2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G462V	TCGA-29-1777	OV	TCGA	ITPYGE	LIG_APCC_ABBA_1	458:463	Mutation altering degron motif	0.6421
p.G462V	DO28071	OV	ICGC	ITPYGE	LIG_APCC_ABBA_1	458:463	Mutation altering degron motif	0.6421
p.G462R	TCGA-29-1777	OV	TCGA	ITPYGE	LIG_APCC_ABBA_1	458:463	Mutation altering degron motif	0.6457
p.G462R	DO28071	OV	ICGC	ITPYGE	LIG_APCC_ABBA_1	458:463	Mutation altering degron motif	0.6457
p.I472M	TCGA-50-6590	LUAD	TCGA	ITPYGE	LIG_APCC_ABBA_1	458:463	Mutation rewiring degron network	0.0833
p.I472M	TCGA-VS-A8QM	CESC	TCGA	ITPYGE	LIG_APCC_ABBA_1	458:463	Mutation rewiring degron network	0.0833
p.I472M	DO51631	CESC	ICGC	ITPYGE	LIG_APCC_ABBA_1	458:463	Mutation rewiring degron network	0.0833
p.I472M	DO24692	LUAD	ICGC	ITPYGE	LIG_APCC_ABBA_1	458:463	Mutation rewiring degron network	0.0833
p.T459N	TCGA-AA-3852	COAD	TCGA	ITPYGE	LIG_APCC_ABBA_1	458:463	Mutation altering degron motif	0.5944
p.T459N	DO8471	COAD	ICGC	ITPYGE	LIG_APCC_ABBA_1	458:463	Mutation altering degron motif	0.5944
p.P460S	TCGA-BF-AAOX	SKCM	TCGA	ITPYGE	LIG_APCC_ABBA_1	458:463	Mutation altering degron motif	0.6752
p.P460S	DO223907	SKCM	ICGC	ITPYGE	LIG_APCC_ABBA_1	458:463	Mutation altering degron motif	0.6752
p.A456T	DO228483	BRCA	ICGC	ITPYGE	LIG_APCC_ABBA_1	458:463	Mutation rewiring degron network	0.2778
p.A456T	DO229010	COCA	ICGC	ITPYGE	LIG_APCC_ABBA_1	458:463	Mutation rewiring degron network	0.2778
p.A456T	DO229473	LAML	ICGC	ITPYGE	LIG_APCC_ABBA_1	458:463	Mutation rewiring degron network	0.2778
p.A456T	DO231140	LAML	ICGC	ITPYGE	LIG_APCC_ABBA_1	458:463	Mutation rewiring degron network	0.2778
p.A456T	DO228947	LICA	ICGC	ITPYGE	LIG_APCC_ABBA_1	458:463	Mutation rewiring degron network	0.2778
p.Y471S	DO229293	LMS	ICGC	ITPYGE	LIG_APCC_ABBA_1	458:463	Mutation rewiring degron network	0.1111
p.W459C	22RV1	prostate	COSMIC	ITPYGE	LIG_APCC_ABBA_1	458:463	Mutation altering degron motif	0.7
p.K472N	MEG-01	haematopoietic and lymphoid tissue	COSMIC	ITPYGE	LIG_APCC_ABBA_1	458:463	Mutation rewiring degron network	0.0833
p.K472N	U-266	haematopoietic and lymphoid tissue	COSMIC	ITPYGE	LIG_APCC_ABBA_1	458:463	Mutation rewiring degron network	0.0833
p.C451F	HARA	lung	COSMIC	ITPYGE	LIG_APCC_ABBA_1	458:463	Mutation rewiring degron network	0.1389

Kaplan plot for EDEM2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EDEM2

UniProt ID: Q9BV94

Entrez ID: 55741

Protein name: ER degradation-enhancing alpha-mannosidase-like protein 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EDEM2 in