DegronMD

Uniprot ID: Q9BV94

Source protein: ER degradation-enhancing alpha-mannosidase-like protein 2

Source gene: EDEM2

Class: LIG_APCC_ABBA_1

Location: 458:463

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5369

ASA_SCORE: 65.5333

COIL: 0.6177

CONS_SCORE: 0.3387

DSS_SCORE: 0.0463

HELIX: 0.0328

FCONS_SCORE: 0.7485

RIG_SCORE: 0.912

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G462V	TCGA-29-1777	OV	TCGA	ITPYGE	LIG_APCC_ABBA_1	0.6421
p.G462V	DO28071	OV	ICGC	ITPYGE	LIG_APCC_ABBA_1	0.6421
p.G462R	TCGA-29-1777	OV	TCGA	ITPYGE	LIG_APCC_ABBA_1	0.6457
p.G462R	DO28071	OV	ICGC	ITPYGE	LIG_APCC_ABBA_1	0.6457
p.I472M	TCGA-50-6590	LUAD	TCGA	ITPYGE	LIG_APCC_ABBA_1	0.0833
p.I472M	TCGA-VS-A8QM	CESC	TCGA	ITPYGE	LIG_APCC_ABBA_1	0.0833
p.I472M	DO51631	CESC	ICGC	ITPYGE	LIG_APCC_ABBA_1	0.0833
p.I472M	DO24692	LUAD	ICGC	ITPYGE	LIG_APCC_ABBA_1	0.0833
p.T459N	TCGA-AA-3852	COAD	TCGA	ITPYGE	LIG_APCC_ABBA_1	0.5944
p.T459N	DO8471	COAD	ICGC	ITPYGE	LIG_APCC_ABBA_1	0.5944
p.P460S	TCGA-BF-AAOX	SKCM	TCGA	ITPYGE	LIG_APCC_ABBA_1	0.6752
p.P460S	DO223907	SKCM	ICGC	ITPYGE	LIG_APCC_ABBA_1	0.6752
p.A456T	DO228483	BRCA	ICGC	ITPYGE	LIG_APCC_ABBA_1	0.2778
p.A456T	DO229010	COCA	ICGC	ITPYGE	LIG_APCC_ABBA_1	0.2778
p.A456T	DO229473	LAML	ICGC	ITPYGE	LIG_APCC_ABBA_1	0.2778
p.A456T	DO231140	LAML	ICGC	ITPYGE	LIG_APCC_ABBA_1	0.2778
p.A456T	DO228947	LICA	ICGC	ITPYGE	LIG_APCC_ABBA_1	0.2778
p.Y471S	DO229293	LMS	ICGC	ITPYGE	LIG_APCC_ABBA_1	0.1111
p.W459C	22RV1	prostate	COSMIC	ITPYGE	LIG_APCC_ABBA_1	0.7
p.K472N	MEG-01	haematopoietic_and_lymphoid_tissue	COSMIC	ITPYGE	LIG_APCC_ABBA_1	0.0833
p.K472N	U-266	haematopoietic_and_lymphoid_tissue	COSMIC	ITPYGE	LIG_APCC_ABBA_1	0.0833
p.C451F	HARA	lung	COSMIC	ITPYGE	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BV94	ER degradation-enhancing alpha-mannosidase-like protein 2	LIG_APCC_ABBA_1	458:463	ITPYGE	APC,CDC20,FZR1	0.5369	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons