FUNCTION: Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtu...
FUNCTION: Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. {ECO:0000255|HAMAP-Rule:MF_03022, ECO:0000269|PubMed:10751153}.
View more >>
GO - Biological processes (BP):
cell division [GO:0051301]; microtubule depolymerization [GO:0007019]; microtubule severing [GO:0051013]; mitotic chromosome movement towards spindle pole [GO:0007079]; negative regulation of microtubule depolymerization [GO:0007026]; positive regulation of cell death [GO:0010942]; positive regulati...
cell division [GO:0051301]; microtubule depolymerization [GO:0007019]; microtubule severing [GO:0051013]; mitotic chromosome movement towards spindle pole [GO:0007079]; negative regulation of microtubule depolymerization [GO:0007026]; positive regulation of cell death [GO:0010942]; positive regulation of microtubule depolymerization [GO:0031117]; positive regulation of neuron projection development [GO:0010976]; protein targeting [GO:0006605]
View more >>
GO - Molecular function (MF):
ATPase regulator activity [GO:0060590]; dynein complex binding [GO:0070840]; microtubule binding [GO:0008017]; protein heterodimerization activity [GO:0046982]...
ATPase regulator activity [GO:0060590]; dynein complex binding [GO:0070840]; microtubule binding [GO:0008017]; protein heterodimerization activity [GO:0046982]
View more >>
GO - Cellular component (CC):
centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; growth cone [GO:0030426]; katanin complex [GO:0008352]; membrane [GO:0016020]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; plasma m...
centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; growth cone [GO:0030426]; katanin complex [GO:0008352]; membrane [GO:0016020]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spindle [GO:0005819]; spindle pole [GO:0000922]
View more >>