DegronMD

Uniprot ID: Q9BVA0

Source protein: Katanin p80 WD40 repeat-containing subunit B1

Source gene: KATNB1

Class: DEG_SCF_FBW7_1

Location: 1:7

E3 ligase: FBXW7

DEGRON score: 0.7815

ASA_SCORE: 93.1714

COIL: 0.909

CONS_SCORE: 0.3604

DSS_SCORE: 0.5981

HELIX: 0.0376

FCONS_SCORE: 0.6487

RIG_SCORE: 0.8218

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A2T	TCGA-AP-A1DK	UCEC	TCGA	MATPVVT	DEG_SCF_FBW7_1	0.6028
p.A2T	DO42033	UCEC	ICGC	MATPVVT	DEG_SCF_FBW7_1	0.6028
p.V17I	TCGA-T2-A6X0	HNSC	TCGA	MATPVVT	DEG_SCF_FBW7_1	0.0556
p.V17I	DO219069	HNSC	ICGC	MATPVVT	DEG_SCF_FBW7_1	0.0556
p.V17I	SIDM00370	T-Lymphoblastic Leukemia	GDSC	MATPVVT	DEG_SCF_FBW7_1	0.0556
p.V17I	TALL-1	haematopoietic_and_lymphoid_tissue	COSMIC	MATPVVT	DEG_SCF_FBW7_1	0.0556
p.T7I	ACH-000634	Brain Cancer	CCLE	MATPVVT	DEG_SCF_FBW7_1	0.7078
p.P4A	ACH-001033	Unknown	CCLE	MATPVVT	DEG_SCF_FBW7_1	0.7503

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BVA0	Katanin p80 WD40 repeat-containing subunit B1	DEG_SCF_FBW7_1	1:7	MATPVVT	FBXW7	0.7815	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons