DegronMD - Q9BVG8(KIFC3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H173Q	TCGA-64-1677	LUAD	TCGA	LRDKLSQLQ	DEG_APCC_DBOX_1	180:188	Mutation rewiring degron network	0.1389
p.E193G	TCGA-AJ-A8CT	UCEC	TCGA	LRDKLSQLQ	DEG_APCC_DBOX_1	180:188	Mutation rewiring degron network	0.1944
p.M191V	TCGA-DD-AAD5	LIHC	TCGA	LRDKLSQLQ	DEG_APCC_DBOX_1	180:188	Mutation rewiring degron network	0.25
p.A192V	TCGA-G4-6309	COAD	TCGA	LRDKLSQLQ	DEG_APCC_DBOX_1	180:188	Mutation rewiring degron network	0.2222
p.R177Q	DO234307	ESAD	ICGC	LRDKLSQLQ	DEG_APCC_DBOX_1	180:188	Mutation rewiring degron network	0.25
p.R177Q	DO233259	GACA	ICGC	LRDKLSQLQ	DEG_APCC_DBOX_1	180:188	Mutation rewiring degron network	0.25
p.E184K	DO233280	GACA	ICGC	LRDKLSQLQ	DEG_APCC_DBOX_1	180:188	Mutation altering degron motif	0.7022
p.E184K	DO36556	READ	ICGC	LRDKLSQLQ	DEG_APCC_DBOX_1	180:188	Mutation altering degron motif	0.7022
p.R180C	DO233830	GACA	ICGC	LRDKLSQLQ	DEG_APCC_DBOX_1	180:188	Mutation altering degron motif	0.8301
p.R190W	DO51784	STAD	ICGC	LRDKLSQLQ	DEG_APCC_DBOX_1	180:188	Mutation rewiring degron network	0.2778
p.P195H	DO42312	UCEC	ICGC	LRDKLSQLQ	DEG_APCC_DBOX_1	180:188	Mutation blocking ubiquitination signal	0.5833
p.R174W	DO43634	UCEC	ICGC	LRDKLSQLQ	DEG_APCC_DBOX_1	180:188	Mutation rewiring degron network	0.1667
p.T185I	DO41235	UCEC	ICGC	LRDKLSQLQ	DEG_APCC_DBOX_1	180:188	Mutation altering degron motif	0.7078
p.H195Y	SIDM01293	Colorectal Carcinoma	GDSC	LRDKLSQLQ	DEG_APCC_DBOX_1	180:188	Mutation blocking ubiquitination signal	0.5833
p.A176V	ACH-000989	Colon/Colorectal Cancer	CCLE	LRDKLSQLQ	DEG_APCC_DBOX_1	180:188	Mutation rewiring degron network	0.2222
p.A176V	SNU-175	large intestine	COSMIC	LRDKLSQLQ	DEG_APCC_DBOX_1	180:188	Mutation rewiring degron network	0.2222
p.R181C	KCL-22	haematopoietic and lymphoid tissue	COSMIC	LRDKLSQLQ	DEG_APCC_DBOX_1	180:188	Mutation altering degron motif	0.8301

Kaplan plot for KIFC3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIFC3

UniProt ID: Q9BVG8

Entrez ID: 3801

Protein name: Kinesin-like protein KIFC3

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KIFC3 in