DegronMD

Uniprot ID: Q9BVG8

Source protein: Kinesin-like protein KIFC3

Source gene: KIFC3

Class: DEG_APCC_DBOX_1

Location: 180:188

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6385

ASA_SCORE: 92.8778

COIL: 0.0182

CONS_SCORE: 0.3266

DSS_SCORE: 0.504

HELIX: 0.9828

FCONS_SCORE: 1.0625

RIG_SCORE: 0.7545

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H173Q	TCGA-64-1677	LUAD	TCGA	LRDKLSQLQ	DEG_APCC_DBOX_1	0.1389
p.E193G	TCGA-AJ-A8CT	UCEC	TCGA	LRDKLSQLQ	DEG_APCC_DBOX_1	0.1944
p.M191V	TCGA-DD-AAD5	LIHC	TCGA	LRDKLSQLQ	DEG_APCC_DBOX_1	0.25
p.A192V	TCGA-G4-6309	COAD	TCGA	LRDKLSQLQ	DEG_APCC_DBOX_1	0.2222
p.R177Q	DO234307	ESAD	ICGC	LRDKLSQLQ	DEG_APCC_DBOX_1	0.25
p.R177Q	DO233259	GACA	ICGC	LRDKLSQLQ	DEG_APCC_DBOX_1	0.25
p.E184K	DO233280	GACA	ICGC	LRDKLSQLQ	DEG_APCC_DBOX_1	0.7022
p.E184K	DO36556	READ	ICGC	LRDKLSQLQ	DEG_APCC_DBOX_1	0.7022
p.R180C	DO233830	GACA	ICGC	LRDKLSQLQ	DEG_APCC_DBOX_1	0.8301
p.R190W	DO51784	STAD	ICGC	LRDKLSQLQ	DEG_APCC_DBOX_1	0.2778
p.P195H	DO42312	UCEC	ICGC	LRDKLSQLQ	DEG_APCC_DBOX_1	0.5833
p.R174W	DO43634	UCEC	ICGC	LRDKLSQLQ	DEG_APCC_DBOX_1	0.1667
p.T185I	DO41235	UCEC	ICGC	LRDKLSQLQ	DEG_APCC_DBOX_1	0.7078
p.H195Y	SIDM01293	Colorectal Carcinoma	GDSC	LRDKLSQLQ	DEG_APCC_DBOX_1	0.5833
p.A176V	ACH-000989	Colon/Colorectal Cancer	CCLE	LRDKLSQLQ	DEG_APCC_DBOX_1	0.2222
p.A176V	SNU-175	large_intestine	COSMIC	LRDKLSQLQ	DEG_APCC_DBOX_1	0.2222
p.R181C	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	LRDKLSQLQ	DEG_APCC_DBOX_1	0.8301

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BVG8	Kinesin-like protein KIFC3	DEG_APCC_DBOX_1	180:188	LRDKLSQLQ	APC,CDC20,FZR1	0.6385	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons