DegronMD - Q9BVS4(RIOK2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S456P	TCGA-44-A47B	LUAD	TCGA	FRPFRD	LIG_APCC_ABBA_1	462:467	Mutation rewiring degron network	0.1667
p.S456P	DO45353	LUAD	ICGC	FRPFRD	LIG_APCC_ABBA_1	462:467	Mutation rewiring degron network	0.1667
p.S456L	TCGA-AX-A2HC	UCEC	TCGA	FRPFRD	LIG_APCC_ABBA_1	462:467	Mutation rewiring degron network	0.1667
p.S456L	TCGA-QB-AA9O	SKCM	TCGA	FRPFRD	LIG_APCC_ABBA_1	462:467	Mutation rewiring degron network	0.1667
p.S456L	DO51267	SKCM	ICGC	FRPFRD	LIG_APCC_ABBA_1	462:467	Mutation rewiring degron network	0.1667
p.S456L	DO41572	UCEC	ICGC	FRPFRD	LIG_APCC_ABBA_1	462:467	Mutation rewiring degron network	0.1667
p.S456L	SIDM00282	Colorectal Carcinoma	GDSC	FRPFRD	LIG_APCC_ABBA_1	462:467	Mutation rewiring degron network	0.1667
p.S456L	ACH-000998	Colon/Colorectal Cancer	CCLE	FRPFRD	LIG_APCC_ABBA_1	462:467	Mutation rewiring degron network	0.1667
p.S456L	CW-2	large intestine	COSMIC	FRPFRD	LIG_APCC_ABBA_1	462:467	Mutation rewiring degron network	0.1667
p.A454D	TCGA-B5-A11E	UCEC	TCGA	FRPFRD	LIG_APCC_ABBA_1	462:467	Mutation rewiring degron network	0.1111
p.A454D	DO41644	UCEC	ICGC	FRPFRD	LIG_APCC_ABBA_1	462:467	Mutation rewiring degron network	0.1111
p.M474I	TCGA-G2-AA3D	BLCA	TCGA	FRPFRD	LIG_APCC_ABBA_1	462:467	Mutation rewiring degron network	0.1389
p.M474I	DO51884	BLCA	ICGC	FRPFRD	LIG_APCC_ABBA_1	462:467	Mutation rewiring degron network	0.1389
p.E461Q	TCGA-KP-A3W3	UCEC	TCGA	FRPFRD	LIG_APCC_ABBA_1	462:467	Mutation rewiring degron network	0.3056
p.E461Q	DO219780	UCEC	ICGC	FRPFRD	LIG_APCC_ABBA_1	462:467	Mutation rewiring degron network	0.3056
p.F462S	DO227646	COCA	ICGC	FRPFRD	LIG_APCC_ABBA_1	462:467	Mutation altering degron motif	0.7982
p.R463K	DO227968	COCA	ICGC	FRPFRD	LIG_APCC_ABBA_1	462:467	Mutation altering degron motif	0.6126
p.A473D	DO229015	LICA	ICGC	FRPFRD	LIG_APCC_ABBA_1	462:467	Mutation rewiring degron network	0.1667
p.E461K	DO26599	LUSC	ICGC	FRPFRD	LIG_APCC_ABBA_1	462:467	Mutation rewiring degron network	0.3056
p.S471L	DO42312	UCEC	ICGC	FRPFRD	LIG_APCC_ABBA_1	462:467	Mutation rewiring degron network	0.2222
p.S471L	SIDM01611	Endometrial Carcinoma	GDSC	FRPFRD	LIG_APCC_ABBA_1	462:467	Mutation rewiring degron network	0.2222
p.P464S	SIDM00333	Endometrial Carcinoma	GDSC	FRPFRD	LIG_APCC_ABBA_1	462:467	Mutation altering degron motif	0.6752
p.P464S	ACH-000988	Endometrial/Uterine Cancer	CCLE	FRPFRD	LIG_APCC_ABBA_1	462:467	Mutation altering degron motif	0.6752
p.P464S	MFE-319	endometrium	COSMIC	FRPFRD	LIG_APCC_ABBA_1	462:467	Mutation altering degron motif	0.6752
p.L455V	SIDM00404	B-Cell Non-Hodgkin's Lymphoma	GDSC	FRPFRD	LIG_APCC_ABBA_1	462:467	Mutation rewiring degron network	0.1389
p.L455V	ACH-002307	Lymphoma	CCLE	FRPFRD	LIG_APCC_ABBA_1	462:467	Mutation rewiring degron network	0.1389
p.L455V	SU-DHL-16	haematopoietic and lymphoid tissue	COSMIC	FRPFRD	LIG_APCC_ABBA_1	462:467	Mutation rewiring degron network	0.1389
p.L455S	SIDM01105	Melanoma	GDSC	FRPFRD	LIG_APCC_ABBA_1	462:467	Mutation rewiring degron network	0.1389

Kaplan plot for RIOK2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RIOK2

UniProt ID: Q9BVS4

Entrez ID: 55781

Protein name: Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RIOK2 in