DegronMD

Uniprot ID: Q9BVS4

Source protein: Serine/threonine-protein kinase RIO2

Source gene: RIOK2

Class: LIG_APCC_ABBA_1

Location: 462:467

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9572

ASA_SCORE: 98.5833

COIL: 0.7517

CONS_SCORE: 0.2913

DSS_SCORE: 0.3996

HELIX: 0.1855

FCONS_SCORE: 1.0145

RIG_SCORE: 0.7885

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S456P	TCGA-44-A47B	LUAD	TCGA	FRPFRD	LIG_APCC_ABBA_1	0.1667
p.S456P	DO45353	LUAD	ICGC	FRPFRD	LIG_APCC_ABBA_1	0.1667
p.S456L	TCGA-AX-A2HC	UCEC	TCGA	FRPFRD	LIG_APCC_ABBA_1	0.1667
p.S456L	TCGA-QB-AA9O	SKCM	TCGA	FRPFRD	LIG_APCC_ABBA_1	0.1667
p.S456L	DO51267	SKCM	ICGC	FRPFRD	LIG_APCC_ABBA_1	0.1667
p.S456L	DO41572	UCEC	ICGC	FRPFRD	LIG_APCC_ABBA_1	0.1667
p.S456L	SIDM00282	Colorectal Carcinoma	GDSC	FRPFRD	LIG_APCC_ABBA_1	0.1667
p.S456L	ACH-000998	Colon/Colorectal Cancer	CCLE	FRPFRD	LIG_APCC_ABBA_1	0.1667
p.S456L	CW-2	large_intestine	COSMIC	FRPFRD	LIG_APCC_ABBA_1	0.1667
p.A454D	TCGA-B5-A11E	UCEC	TCGA	FRPFRD	LIG_APCC_ABBA_1	0.1111
p.A454D	DO41644	UCEC	ICGC	FRPFRD	LIG_APCC_ABBA_1	0.1111
p.M474I	TCGA-G2-AA3D	BLCA	TCGA	FRPFRD	LIG_APCC_ABBA_1	0.1389
p.M474I	DO51884	BLCA	ICGC	FRPFRD	LIG_APCC_ABBA_1	0.1389
p.E461Q	TCGA-KP-A3W3	UCEC	TCGA	FRPFRD	LIG_APCC_ABBA_1	0.3056
p.E461Q	DO219780	UCEC	ICGC	FRPFRD	LIG_APCC_ABBA_1	0.3056
p.F462S	DO227646	COCA	ICGC	FRPFRD	LIG_APCC_ABBA_1	0.7982
p.R463K	DO227968	COCA	ICGC	FRPFRD	LIG_APCC_ABBA_1	0.6126
p.A473D	DO229015	LICA	ICGC	FRPFRD	LIG_APCC_ABBA_1	0.1667
p.E461K	DO26599	LUSC	ICGC	FRPFRD	LIG_APCC_ABBA_1	0.3056
p.S471L	DO42312	UCEC	ICGC	FRPFRD	LIG_APCC_ABBA_1	0.2222
p.S471L	SIDM01611	Endometrial Carcinoma	GDSC	FRPFRD	LIG_APCC_ABBA_1	0.2222
p.P464S	SIDM00333	Endometrial Carcinoma	GDSC	FRPFRD	LIG_APCC_ABBA_1	0.6752
p.P464S	ACH-000988	Endometrial/Uterine Cancer	CCLE	FRPFRD	LIG_APCC_ABBA_1	0.6752
p.P464S	MFE-319	endometrium	COSMIC	FRPFRD	LIG_APCC_ABBA_1	0.6752
p.L455V	SIDM00404	B-Cell Non-Hodgkin's Lymphoma	GDSC	FRPFRD	LIG_APCC_ABBA_1	0.1389
p.L455V	ACH-002307	Lymphoma	CCLE	FRPFRD	LIG_APCC_ABBA_1	0.1389
p.L455V	SU-DHL-16	haematopoietic_and_lymphoid_tissue	COSMIC	FRPFRD	LIG_APCC_ABBA_1	0.1389
p.L455S	SIDM01105	Melanoma	GDSC	FRPFRD	LIG_APCC_ABBA_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FRPFRD

Degron related mutations and impact score

Drug responses associated with RIOK2 mutations

All proteins holding degron of FRPFRD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BVS4	Serine/threonine-protein kinase RIO2	LIG_APCC_ABBA_1	462:467	FRPFRD	APC,CDC20,FZR1	0.9572	More...